BACKGROUND feeding/eating disorders are frequent in pediatric patients and, in some cases, can be associated to an upper digestive motility disorder. Gastro-esophageal reflux is, nowadays, considered a risk factor for the development of feeding/eating disorders. AIM to verify the occurrence of feeding/eating disorders in patients with Gastro-Esophageal Reflux Disease (GERD) determined by the ...

Concepts of the spectrum of gastroesophageal reflux disease (GERD) continue to evolve as researchers and clinicians challenge conceptual frameworks and explore new paradigms aided by innovative technologies and novel developments in symptom assessment. In this review, the deliberations of a meeting of experts in gastroenterology (Athens, 2006) are presented as a critical evaluation of the curre...

Transient receptor potential vanilloid-1 (TRPV1) receptor and proteinase-activated receptor 2 (PAR2) have been implicated in the mechanism of acid-induced inflammation in gastroesophageal reflux disease (GERD). We aimed to evaluate TRPV1 and PAR2 mRNA expression levels in the GERD patients and their relationship with endoscopic findings and reflux symptoms.Sixteen healthy controls, 45 patients ...

The endoscopic abnormalities that may be seen in association with esophageal disorders are numerous, varying from subtle alterations in the esophageal mucosal surface to large ulcers or masses. This discussion will be focused on a few commonly encountered entities in which clinical, endoscopic and histologic correlation are critical for establishing a correct diagnosis. These include gastroesop...

It is important to understand sex and gender-related differences in gastroesophageal reflux disease (GERD) because gender-related biologic factors might lead to better prevention and therapy. Non-erosive reflux disease (NERD) affects more women than men. GERD symptoms are more frequent in patients with NERD than in those with reflux esophagitis. However, men suffer pathologic diseases such as r...

OBJECTIVE To determine the prevalence of gastroesophageal reflux disease (GERD) and to evaluate the esophageal motor profile of patients with respiratory symptoms referred to a digestive motility referral center for esophageal function testing. METHODS The results of esophageal manometry and 24-h esophageal pH-metry were analyzed.The inclusion criterion was presenting respiratory symptoms, wi...

BACKGROUND/AIMS Recent studies suggest that the prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea. However, studies on risk factors for GERD have yielded inconsistent results. The aims of this study were to compare clinical features between symptomatic syndromes without esophageal injury (=non-erosive disease [NED]) and syndromes with esophageal injury (=erosive diseas...

Multiple factors play a role in the pathogenesis of gastroesophageal reflux disease (GERD). Two landmark studies showing higher concordance of disease in monozygotic than dizygotic twin pairs suggested the role of host genetic factors in its pathogenesis. Recent studies have shown that genetic polymorphism in genes influencing host's inflammatory response, drug metabolism, cell cycle regulation...

Gastroesophageal reflux disease (GERD) merupakan suatu keadaan melemahnya Lower Esophageal Sphincter (LES) yang mengakibatkan terjadinya refluks cairan asam lambung ke dalam esophagus dan menimbulkan gejala khas seperti heartburn. Kecemasan sangat akrab dengan kehidupan manusia, kecemasan dapat digamarkan kegugupan, ketakutan rasa tidak aman sering disertai ancaman berbahaya pada individu, GERD...

BACKGROUND Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30-80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of pregnancy. Furthermore current practice in medical care for GERD during pregnancy was assessed. METHODS We performed a prospective longitudinal cohort study on 510 pregnant wo...