We have investigated the effects of cigarette smoke exposure in three different strains of mice. DBA/2 and C57BL/6J are susceptible to smoke and develop different lung changes in response to chronic exposure, whereas ICR mice are resistant to smoke and do not develop emphysema. The present study was carried out to determine early changes in the gene expression profile of mice exposed to cigaret...

TO THE EDITOR: We read with interest the article by Aravamudan and colleagues (1) on cigarette smoke-induced mitochondrial fragmentation and dysfunction in human airway smooth muscle. As explained in a recent Perspectives (4), mitochondria are at the center of a reactive oxygen species-dependent pathway regulating cellular cytotoxic responses. The study by Aravamudan et al. demonstrates that ci...

BACKGROUND Exposure to secondhand smoke causes lung cancer; however, there are little data in the open literature on the in vivo toxicology of fresh sidestream cigarette smoke to guide the debate about smoke-free workplaces and public places. OBJECTIVE To investigate the unpublished in vivo research on sidestream cigarette smoke done by Philip Morris Tobacco Company during the 1980s at its In...

The morbidity and mortality of burn victims increase when burn injury is combined with smoke inhalation. The goal of the present study was to develop a murine model of burn and smoke inhalation injury to more precisely reveal the mechanistic aspects of these pathological changes. The burn injury mouse group received a 40% total body surface area third-degree burn alone, the smoke inhalation inj...

Cannabis is the most widely used illicit drug in the world. Delta-9-tetrahydrocannabinol (Δ9-THC) is the main psychoactive component of cannabis and its effects have been well-studied. However, cannabis contains many other cannabinoids that affect brain function. Therefore, these studies investigated the effect of cannabis smoke exposure on locomotor activity, rearing, anxiety-like behavior, an...

OBJECTIVE To determine prevalence and factors associated with strictly enforced smoke-free car policies among smoking parents. METHODS As part of a cluster, randomized controlled trial addressing parental smoking, exit interviews were conducted with parents whose children were seen in 10 control pediatric practices. Parents who smoked were asked about smoking behaviors in their car and receip...

BACKGROUND AND AIMS A major germination-promoting chemical in smoke-water is 3-methyl-2H-furo[2,3-c]pyran-2-one (karrikinolide, KAR(1)). However, not all species that germinate in response to smoke-water are responsive to KAR(1), such as Tersonia cyathiflora (Gyrostemonaceae). In this study, a test was made of whether two Gyrostemon species (Gyrostemonaceae) that have previously been shown to r...

we have produced a spectrum of limb defects in developing mouse embryos by exposing the mother to smoke from cigarettes with different nicotine concentrations, ethanol, and a combination of ethanol and cigarette smoke. the critical time of exposure was determined to be during day 10 of gestation (vaginal plug=day 0). this time is prior to the critical events which occur between the apical ectod...

An analysis of the requirements for mechanical smoke exhaust in large space buildings was made and some experiments in a fire test atrium have been performed. It can be concluded that the temperature of smoke in large space building fire is usually quite low which makes them easy to descend and to mix with air. Usually it’s difficult to control the descending of a smoke layer effectively when t...

In vitro analysis of fresh smoke is an important part of cigarette testing because the exposure methods employed may reflect human smoke exposure. Whole smoke is a dynamic system and has to be handled accordingly. In a few seconds smoke changes its properties. Therefore, the period of time until the smoke is in contact with cells has to be kept as short as possible. The same preconditions need ...