Opioids are respiratory depressants and heroin/opioid overdose is a major contributor to the excess mortality of heroin addicts. The individual and situational variability of respiratory depression caused by intravenous heroin is poorly understood. This study used advanced respiratory monitoring to follow the time course and severity of acute opioid-induced respiratory depression. 10 patients (...

BACKGROUND To shorten emergence time after a procedure using volatile anesthesia, 78% of anesthesiologists recently surveyed used hyperventilation to rapidly clear the anesthetic from the lungs. Hyperventilation has not been universally adapted into clinical practice because it also decreases the Paco2, which decreases cerebral bloodflow and depresses respiratory drive. Adding deadspace to the ...

Objective: The main objective of this study was to compare the effects minimal and high gas flow-controlled hypotension applications on IMA thiol/disulfide balance, which are indicators oxidative stress.Methods: Patients undergoing elective tympanoplasty were randomized two groups as minimal-flow high-flow anesthesia groups. Minimal flow performed with 5L/min fresh reduced 0.4 L/min. High admin...

Increased intrabdominal pressure induced by pneumoperitoneum induces modifications in cardiovascular and respiratory systems. The aim of the study was to analyze the hemodynamic and respiratory modifications produced by pneumoperitoneum during living donor nephrectomy in a porcine experimental model. Twenty pigs underwent left nephrectomy, 10 by laparoscopy and 10 by an open approach. The follo...

BACKGROUND Baby EAR circuit is a new modified enclosed afferent reservoir anesthetic breathing system invented to use in pediatric patients. By following His Majesty the King of Thailand's self-sufficiency philosophy, the circuit is simplymade of low-cost and easy-to-find materials in the operating room. OBJECTIVE Investigate clinical use of the circuit and to find the optimal fresh gas flow ...

OBJECTIVE To determine whether the respiratory response to resuscitation in infants with congenital diaphragmatic hernia (CDH) as measured by a respiratory function monitor differed between those who did and did not survive. DESIGN Observational study. SETTING Tertiary perinatal centre. PATIENTS Thirty-eight infants born at 34 weeks of gestation or greater and diagnosed antenatally with a...

Background: Ventilator management for children with hypoxemic respiratory failure may benefit from ventilator protocols, which rely on blood gases. Accurate non-invasive estimates for pH or PaCO2 could allow frequent ventilator changes to optimize lung protective ventilation strategies. If these models are highly accurate, they can facilitate the development of closed-loop ventilator systems. W...

Intact cerebral blood flow (CBF) is essential for cerebral metabolism and function, whereas hypoperfusion in relation to hypovolemia and hypocapnia can lead to severe cerebral damage. This study was designed to assess internal carotid artery blood flow (ICA-BF) during simulated hypovolemia and noninvasive positive pressure ventilation (PPV) in young healthy humans. Beat-by-beat blood velocity (...

We investigated the effectiveness of automated pupillometry on monitoring cardiopulmonary resuscitation (CPR) and predicting return spontaneous circulation (ROSC) in a swine model cardiac arrest (CA). Sixteen male domestic pigs were included. Traditional indices including coronary perfusion pressure (CPP), end-tidal carbon dioxide (ETCO2), regional cerebral tissue oxygen saturation (rSO2) carot...

Corresponding author: Seok-Hee Han, M.D., Department of Anesthesiology and Pain Medicine, Cheongju St. Mary's Hospital, 589-5, Jujungdong, Sangdang-gu, Cheongju 360-568, Korea. Tel: 82-43-219-8244, Fax: 82-43-219-8112, E-mail: [email protected] This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/lice...