Let J(z) be regular and of exponential type less than wr in the half plane x _ 0, and let I Xn } be an increasing positive sequence of unit density such that Xn+1 -n _ 5 > 0. It is known that under suitable restrictions and with a suitable measure of growth, the growth of the sequence tf(Xn) determines the growth off(x) for real x > 0. I have established the following results. Let e(x) be a con...

Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved among all CMN group bacteria. The arabinogalactan and mycolic acid synthesis pat...

Tuberculosis (TB) is a communicable disease caused by the bacillus Mycobacterium tuberculosis and leading cause of death single infectious agent overall. According to WHO Global TB Report, India contributes 26% global burden TB. Currently, four-drug regimen comprising Rifampicin, Isoniazid, Pyrazinamide, Ethambutol approved for treatment drug-sensitive The management cutaneous adverse drug reac...

Tuberculosis remains the leading cause of death worldwide from any infectious agent and the alarming increase in the annual incidence of new cases has been described as a global emergency. Mycobacterium infection requires simultaneous administration of multiple drugs. Although the majority of treatment courses progress with minor side effects, adverse reactions to antituberculosis drugs occur i...

Rifamycins are active against slowly growing mycobacteria, such as Mycobacterium tuberculosis and Mycobacterium kansasii, but the majority of rifamycins thus far investigated both in vitro and in vivo are inactive or have only modest activity against the Mycobacterium avium complex (MAC). We investigated the activity of three doses of the semisynthetic benzoxazinorifamycin KRM 1648, alone or in...

Mutations at position 306 of embB (embB306) have been proposed as a marker for ethambutol resistance in Mycobacterium tuberculosis; however, recent reports of embB306 mutations in ethambutol-susceptible isolates caused us to question the biological role of this mutation. We tested 1,020 clinical M. tuberculosis isolates with different drug susceptibility patterns and of different geographical o...

Moxifloxacin activity against Mycobacterium avium complex (MAC) was evaluated in vitro against 25 strains. The MIC was determined to range from 0.125 to 2.0 microg/ml. In addition, U937 macrophage monolayers infected with MAC strain 101 (serovar 1) were treated with moxifloxacin (0.25 to 8 microg/ml) daily, and the number of intracellular bacteria was quantitated after 4 days. Moxifloxacin show...