with double endocrine neoplasia type 1. Echoendoscopy (EUS) revealed two nodular hypoechoic lesions (l" Fig. 1), with a color Doppler hypervascular pat− tern located in the pancreas. We carried out an EUS−guided fine−needle aspiration (FNA) biopsy [1] (l" Fig. 2), which showed a neuroendocrine islet tumor in the pathology report 2 weeks later. Tumor sizes were 11 and 7 mm respectively. Because ...

The effects of ethyl alcohol and pig serum administration on the development of preneoplastic hepatic enzyme-altered foci were examined in an in vivo mid-term assay system. Rats were initially given a single dose (200 mg/Kg) intraperitoneal injection of diethylnitrosamine (DEN). Two weeks later, treatment was started with 10% ethanol + 10% sucrose solution, 10% sucrose solution, or tap water as...

Female Swiss-Webster mice were treated daily for 10 days with cocaine (15 mg/kg i.p.) followed by 10 days with saline or ethanol (1.6 g/kg i.p.) or the reverse; following each injection in the experimental conditions locomotion was quantified in photocell cages. In animals given cocaine first, cocaine-induced locomotion was initially high and did not increase further with successive injections....

In this study, the effectiveness of intra-testicular ethanol and calcium chloride administrations was compared for chemical-castration in 12 mixbred young bulls (12-15 months old and 250-400 kg). Ten ml of absolute ethanol or 10 ml of a 30 % calcium chloride solution were administered intra-testicularly in each testicle which were removed with the open surgical technique after 60 days for histo...

Alcoholism can be viewed as a motivational disorder that results from alterations in brain systems for ingestive behavior. Therefore, it was hypothesized that alcohol intake might alter the expression of hypothalamic peptides that stimulate feeding. Earlier studies showed that hypothalamic injection of the feeding-stimulatory peptide, galanin (GAL), increases the release of dopamine (DA) in the...

RATIONALE The endocannabinoid system has been implicated in the neurobiological mechanism underlying drug addiction, especially the primary rewarding dopamine-dependent processes. Therefore, endocannabinoid receptor antagonists, such as the CB1 cannabinoid antagonist rimonabant, have been proposed as candidates for preventive addiction therapies. OBJECTIVES Investigate the possible involvemen...

Thanks to its properties and production pathways, ethanol represents a valuable alternative fossil fuels, with potential benefits in terms of CO 2 , NO x soot emission reduction. The resistance autoignition necessitates an ignition trigger compression-ignition engines for heavy-duty applications, which the current study is diesel pilot injection. simultaneous direct injection pure as main fuel ...

Radiofrequency ablation (RFA) has become mainstream among non-surgical treatment modalities in clinical settings for the treatment of hepatocellular carcinoma. We have previously described the novel combination therapy of percutaneous ethanol injection and RFA (PEI-RFA) and reported that this combination therapy was more effective than RFA alone in terms of the induced volume of coagulated necr...

Recent studies have demonstrated that metabotropic glutamate receptor 5 (mGluR5) antagonists decrease alcohol self-administration and suggest that the anti-craving medication, acamprosate, may also act to decrease mGluR5 function. To address the role of mGluR5 in behavioural actions of ethanol and acamprosate, we compared mutant mice with deletion of the mGluR5 gene and mice treated with a mGlu...

Although ethanol has been considered to be an anxiolytic agent, consumption of ethanol has also been shown to increase plasma adrenocorticotropin and glucocorticoids. The corticotrophin-releasing factor (CRF) receptor 1alpha (CRF-R1) is a G protein-coupled receptor that activates adenylyl cyclase (AC), leading to adrenocorticotropin (and subsequently glucocorticoid) release into the circulation...