We propose a method for the modification of surfaces of microchannels in chips fabricated in polycarbonate (PC) that makes the devices resistant to a range of organic solvents. Coating of PC with branched polyethyleneimine (BPEI) with the use of trimethylpropane triglycidyl ether (TTE) as a linker renders the devices resistant to toluene, benzene, acetonitrile, tetrahydrofuran, dioxane and ethy...

1-Cycloalkyl-2-propene-1-ones were synthesized by electrophilic addition of cycloalkanecarboxylic acid chlorides and its mono- dichloride-substituted derivatives to ethylene in the presence an AlCl3 catalyst at a temperature –10 ÷ –150C dichloroethane medium. The resulting vinyl ketones converted chlorination CCl4 –50C corresponding 1-cycloalkyl-2,3-dichloro-1-propanones, which form 1-R´-3-cycl...

Endocrine disruptive compounds (EDC) alter hormone-stimulated, nuclear receptor-dependent physiological and developmental processes by a variety of mechanisms. One recently identified mode of endocrine disruption is through hormone sensitization, where the EDC modulates intracellular signaling pathways that control nuclear receptor function, thereby regulating receptor transcriptional activity ...

The hydrolysis of haloalkanes to their corresponding alcohols and inorganic halides is catalyzed by alpha/beta-hydrolases called haloalkane dehalogenases. The study of haloalkane dehalogenases is vital for the development of these enzymes if they are to be utilized for bioremediation of organohalide-contaminated industrial waste. We report the kinetic and structural analysis of the haloalkane d...

A series of novel titanium complexes bearing tridentate β-enaminoketonato chelating ligands of type, [R(2)NC(CF(3))C(H)CR(1)O]TiCl(3) (2a: R(1) = Ph, R(2) = -C(6)H(4)OMe(o); 2b: R(1) = Ph, R(2) = -C(9)H(6)N; 2c: R(1) = Ph, R(2) = -C(6)H(4)SMe(o); 2d: R(1) = Ph, R(2) = -C(6)H(4)SPh(o); 2e: R(1) = (t)Bu, R(2) = -C(6)H(4)SPh(o)) and [R(2)NC(R(1))C(H)C(CF(3))O]TiCl(3) (2f: R(1) = Ph, R(2) = -C(6)H(...

Novel synthetic approaches to chiral ethylene-bridged ansa-titanocenes possessing stereogenic centers on the bridging carbon chain are described. A key step in the preparation of these compounds is the double-Skatteberl rearrangement of bis(vinyldibromocyc1opropane) intermediates derived from 1,4-disulfones. The influence of tether substitution on the diastereoselection in ansa-titanocene forma...