A paradigm shift is currently ongoing in the treatment of spasticity in childhood in Japan. Functional posterior rhizotomy (FPR), which was first introduced to Japan in 1996, is best indicated for children with spastic cerebral palsy, regardless of the clinical severity of spasticity. Surgery is generally carried out in the cauda equina, where the posterior root is separated from the anterior o...

This study investigated the antispasticity potential of Sativex in mice. Chronic relapsing experimental allergic encephalomyelitis was induced in adult ABH mice resulting in hind limb spasticity development. Vehicle, Sativex, and baclofen (as a positive control) were injected intravenously and the "stiffness" of limbs assessed by the resistance force against hind limb flexion. Vehicle alone cau...

OBJECTIVES Spasticity can contribute to poor recovery of upper limb function after stroke. This is a preliminary evaluation of the impact of botulinum toxin treatment on disability caused by upper limb spasticity after stroke. METHODS Seventeen patients with severe spasticity and a non-functioning arm were treated with intramuscular botulinum A neurotoxin (median age at treatment 54.5 years; ...

Spasticity is mostly due to an excess of impulses to alpha motor neurons partly resulting from a change of interneuron activity. Low threshold afferent has been reported to change the activity in interneuron. The purpose of this study is to investigate the effects of surface spinal paravertebral stimulation on knee extensor spasticity. Ten survivors of stroke, with knee extensor spasticity, rec...

OBJECTIVES This article provides an overview of the Upper Limb International Spasticity (ULIS) programme, which aims to develop a common core dataset for evaluation of real-life practice and outcomes in the treatment of upper-limb spasticity with botulinum toxin A (BoNT-A). Here we present the study protocol for ULIS-II, a large, international cohort study, to describe the rationale and steps t...

Background: Spasticity is a motor disorder that appears as cause of upper and lower limb disability, frequently causing pain. IncobotulinumtoxinA (IncoA) has proved effective for treating diverse musculoskeletal pathologies, including spasticity spasticity-related Aims: The aim was to determine the efficacy IncoA treatment pain associated etiologies. Methods: Prospective, single-center study 30...

Spasticity is one of the major complaints of patients with spinal cord injuries. It has negative effects such as limitations in activities of daily living (ADLs), pain, fatigue, sleep disorders, instability, joint contractures, pressure ulcers, and infection, and decreases gait ability through changes in timing of gait-related muscle contraction and cocontraction [1,2]. Spasticity, also, is a m...

Spasticity and stroke: pathophysiology and management rules 2 ARC Publishing in the rheological properties and in the contractile soft tissue and musculoskeletal system (intrinsic hypertonia) are often associated with chronic spasticity and, in turn have been associated with increased spasticity. Signs and symptoms of spasticity: Spasticity signs include muscle stiffness or spasm, muscle spasms...

Spasticity is a common consequence after spinal cord injury (SCI) that affects 53-78 % of individuals with SCI (Maynard, Karunas, & Waring, 1990). Spasticity is defined as increased tonic stretch reflexes and exaggerated tendon jerks (Lance, 1980). Rehabilitation modalities, pharmacologic intervention and surgery are three main therapeutic techniques for spasticity management (Adams & Hicks, 20...

how to cite this article: barzegar m, sayadnasiri m, tabrizi a. epilepsy as a rare neurologic manifestation of oculodentodigitalis dysplasia. iran j child neurol 2012; 6(3): 39-43. oculodentodigitalis dysplasia (oddd) is an extremely rare inherited disorderinvolving the development of the face, eyes, teeth and limbs. in addition,some patients develop neurological problems mostly a spastic parap...