This office consists of six professionals and support personnel concerned with the evaluation of environmental health hazards due mainly to chemical agents. An effort initiated earlier to pull together toxicologic information on organ systems and their diseases in humans with environmental or occupational chemical exposures was continued. It received its impetus when the cause of the Legionaire...

The hazard of adverse effects to aquatic organisms arising from groundwater contaminated with a complex mixture of volatile chlorinated hydrocarbons (CHCs) discharging to Penrhyn Estuary, Sydney, Australia was determined using the hazard quotient (HQ) method. The hazard posed by 14 volatile CHCs acting individually and collectively as a mixture was assessed. The hazard was determined using meas...

Computational prediction of toxicity has reached new heights as a result of decades of growth in the magnitude and diversity of biological data. Public packages for statistics and machine learning make model creation faster. New theory in machine learning and cheminformatics enables integration of chemical structure, toxicogenomics, simulated and physical data in the prediction of chemical heal...

References l.html#ref-list-1 http://rsta.royalsocietypublishing.org/content/364/1845/1965.ful This article cites 25 articles, 5 of which can be accessed free Rapid response 1845/1965 http://rsta.royalsocietypublishing.org/letters/submit/roypta;364/ Respond to this article Email alerting service here in the box at the top right-hand corner of the article or click Receive free email alerts when n...

PURPOSE To report the case of an eye with normal tension glaucoma and a choroidal excavation. METHODS This is an observational case report. RESULTS A 59-year-old woman with normal tension glaucoma had a choroidal excavation in the left eye. Her best-corrected visual acuity and intraocular pressure were within normal limits and had been stable for 5 years. Fundus examination showed a small w...

PURPOSE We reported the clinical and echographic features of colobomas, prevalence of retinal detachment, and associated visual acuity in these patients. METHODS The study is a nonrandomized consecutive case series of 140 colobomatous eyes in 98 patients (age range, 0-83 years). Coloboma depth, width, volume, and relative coloboma excavation (coloboma depth/axial length) were measured using s...

The aims of this in vitro study were both to determine the time necessary for removal of carious dentin (efficiency) and the Knoop Hardness Number (KHN) of the remaining dentin (effectiveness), using a chemomechanical method (Carisolv) or hand excavation. Thirty human molars were bisected through occlusal carious lesions into two equal halves. Each half was randomly excavated by hand in circula...

PURPOSE To report a case of choroidal excavation accompanied by Vogt-Koyanagi-Harada disease (VKH). METHODS A 54-year-old Japanese woman who was complaining of bilateral blurring of vision associated with headache underwent optical coherence tomography (OCT), fluorescein angiography, and indocyanine green angiography as well as a routine ophthalmological examination. RESULTS Fundoscopy show...

One of the areas in which fire hazard assessment techniques have been applied within regulation is for transportation vehicles. In particular, commercial aviation and passenger rail have utilized fire hazard assessment as a means to achieve safety goals well before these techniques became common in buildings. This chapter will review the methods employed and the recent evolution of predictive t...

Landslide hazard assessment is an important step towards landslide hazard and risk management. There are several methods of Landslide Hazard Zonation (LHZ) viz. heuristic, semi quantitative, quantitative, probabilistic and multi-criteria decision making process. However, no one method is accepted universally for effective assessment of landslide hazards. In recent years, several attempts have b...