BACKGROUND Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neurons and copper can be a harmful pro-oxidant, we want to know whether aberrant copper biochemistry co...

Cu-Zn alloys have been electrodeposited from a pyrophosphate electrolyte containing Cu2P207> Zn2P207 salts and an excess of K4P2O7 and KN03. Current-potential data for both copper and zinc, as well their plating current efficiencies were determined from electrochemical polarisation experiments. Copper deposition commenced at potentials below -0.208 V whereas zinc was deposited only below -1.157...

A dysfunction in copper homeostasis seems to occur in Alzheimer's disease (AD). We previously evidenced that an excess of non-ceruloplasmin-copper (NCC) correlated with the main functional, anatomical as well as cerebrospinal markers of the disease. Aim of our study was to investigate ceruloplasmin isoforms as potential actors in this AD copper dysfunction. Our data show that AD patients have c...

Mixed copper-cerium oxides were prepared by two methods leading to different wpper species in the as-prepared material. At the catalyst operating temperature (300400°C) and above, the same copper species was present irrespective of the prepration technique. A solid solution having the same fluorite structure as that of pure CeQ was formed and remained stable after calcination to 100O0C. At temp...

It is well known that excess copper plays a role in the pathogenesis of Wilson's disease; however, the hepatic copper contents, determined either histochemically or biochemically, are not always correlated with the activity of Wilson's disease. To better understand copper-induced cytotoxicity, intrahepatocellular localization of copper was studied in five patients with Wilson's disease. The liv...

Morphological identification of lysosomes was established by acid phosphatase reaction [1]. Pericanalicular lysosomes exhibited lead deposits after incubating liver slices with a lead and phosphate solution under acidic condition. Transitional elements, copper and iron, are stored in lysosomes as detoxified forms of cuprothioneins and hemosiderins, respectively. Genetic background of adult-onse...

Copper is an essential trace element in living organisms with its levels and localisation being carefully managed by the cellular machinery. However, if misregulated, deficiency or excess of copper ions can lead to several diseases. Therefore, it important have reliable methods detect, monitor visualise this metal cells. Herein we report a new optical probe based on BODIPY, which shows switch-o...

In this work the physiological effect of copper excess on the peach rootstock MrS 2/5 and GF 677 was studied by means of an in vitro system. Two different copper treatments (10 and 100 μM CuSO4) for each rootstock were carried out and compared to a control containing 0.1 μM of CuSO4. Relative growth rate and copper concentration inside rootstock tissues were measured after 21 days from the begi...

Copper deprivation of Saccharomyces cerevisiae induces transcription of the FRE1 and CTR1 genes. FRE1 encodes a surface reductase capable of reducing and mobilizing copper chelates outside the cell, and CTR1 encodes a protein mediating copper uptake at the plasma membrane. In this paper, the protein encoded by MAC1 is identified as the factor mediating this homeostatic control. A novel dominant...

INTRODUCTION Outside of Wilson's Disease, abnormal copper metabolism is a rare condition. In pregnancy, excess copper levels can be associated with intrauterine growth restriction, preeclampsia and neurological disease. CASE REPORT A 32 year old Gravida 4 para 2012 with an obstetrical history complicated by elevated copper levels presented for routine prenatal care. Her children had elevated ...