Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are (EVs) different sizes biological functions transported in blood they may be valid NDs. The aim our study was to investigate common miRNA signatures plasma derived LEVs SEVs Alzheimer’s disease (AD), Parkinson’s (PD), Amyotrophic Lateral Sclerosis ...

According to studies, the microbiome may contribute emergence and spread of breast cancer. E. coli is one Enterobacteriaceae family recently found be present as part tissue microbiota. In this study, we focused on effect secretome free cells MCF-7 metabolism. Liquid chromatography–mass spectrometry (LC-MS) metabolomics was used study its role in intra- extracellular metabolites. A comparison ma...

AIM The aim of this study was to evaluate the effect of caffeine on collagen biosynthesis in human skin fibroblasts and the influence of hyaluronic acid (HA) on this process. MATERIALS AND METHODS Collagen, [(3)H]-thymidine incorporation, and prolidase activity were measured in confluent human skin fibroblast cultures that had been treated with 1, 2, and 5 mM caffeine and with caffeine and 50...

The NMDA receptor (NMDAR) plays important roles in excitatory neurotransmission and in the regulation of reproduction in mammals. NMDAR in insects comprises two subunits, NR1 and NR2. In this study, we identified two NR1 paralogs and eleven NR2 alternatively spliced variants in the cockroach Diploptera punctata. This is the first report of NR1 paralogs in insects. The tissue distributions and e...

in this study, silver nanoparticles were synthesized  using the fungus, aspergillus fumigatus. the effects of three independent variables including glucose content of culture media, initial ph and initial spore concentration on biosynthesis of silver nanoparticles were investigated. these variables affect cell morphology, cell mass, size and morphology of silver nanoparticles and degree of silv...

background: pomegranate fruit (punica granatum l.) is a rich source of anthocyanin pigments resulting in vibrant colours and anti-oxidant contents. although the intensity and pattern of anthocyanin biosynthesis in fruit are strongly influenced by r2r3-myb transcription factors, little is known about the regulation and role of myb in anthocyanin pathway of pomegranate.objectives: the present stu...

objective(s): the development of reliable and ecofriendly process for the synthesis of nano-metals is an important aspect in the field of nanotechnology. nano-metals are a special group of materials with broad area of applications. materials and methods: in this study, extracellular synthesis of silver nanoparticles (snps) performed by use of the gram positive soil streptomycetes. streptomycete...

Different environmental nitrogen sources play selective roles in the development of cyanobacterial blooms and noxious effects are often exacerbated when toxic cyanobacteria are dominant. Cylindrospermopsis raciborskii CS-505 (heterocystous, nitrogen fixing) and Raphidiopsis brookii D9 (non-N₂ fixing) produce the nitrogenous toxins cylindrospermopsin (CYN) and paralytic shellfish toxins (PSTs), ...

Lysobacter species have attracted increasing attention in recent years due to their capacities produce diverse secondary metabolites against phytopathogens. In this research, we analyzed the genomic and transcriptomic patterns of capsici CK09. Our data showed that L. CK09 harbored various contact-independent biocontrol traits, such as fungal cell wall lytic enzymes HSAF/WAP-8294A2 biosynthesis,...