Extracellular vesicle (EV)-mediated communication between proximal and distant cells is a highly conserved characteristic in all of the life domains, including bacteria. These vesicles that contain variety biomolecules, such as proteins, lipids, nucleic acids, small-molecule metabolites play key role biology They are one underlying mechanisms behind harmful or beneficial effects many pathogenic...

The metabolism of perazine in a primary culture of human hepatocytes after treatment of cells with TCDD (a CYP1A1/2 inducer) or rifampicin (mainly a CYP3A4 inducer) were studied in vitro. The concentrations of perazine and its main metabolites (perazine 5-sulfoxide, N-desmethylperazine) formed in hepatocytes were assayed in the extracellular medium using the HPLC method. TCDD and rifampicin ind...

There is increased interest in research on yeasts as potential phytopathogen biocontrol agents due to increasing restrictions the use of chemical pesticides. Yeast strains from a range genera and species have been reported inhibit postharvest decay different fruits. However, mechanisms behind these yeast capacities not completely deciphered because they are complex act synergistically. In this ...

The editors of Metabolites would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2016. [...].

BACKGROUND Glioblastomas progress rapidly making response evaluation using MRI insufficient since treatment effects are not detectable until months after initiation of treatment. Thus, there is a strong need for supplementary biomarkers that could provide reliable and early assessment of treatment efficacy. Analysis of alterations in the metabolome may be a source for identification of new biom...

solid phase extraction (spe) cartridge embedded with octadecyl c18 chain bounded to silica particles were used for the isolation and trace enrichment of pesticides from water samples collected from cotton, rice growing and municipal areas. the eluents were analyzed with high performance liquid chromatography (hplc) using methanol (100%) as mobiles phase at different uv-visible wavelengths. ddt ...

Microdialysis is a technique used to measure the concentrations of various compounds in the extracellular fluid of an organ or in a body fluid. It is a form of metabolic monitoring that provides real-time, continuous information on pathophysiological processes in target organs. It was introduced in the early 1970s, mainly to measure concentrations of neurotransmitters in animal experiments and ...