Non-enzymatic glycosylation, commonly known as glycation, is a physiological process that may be intensified by endogenous and exogenous factors. The accumulation of advanced glycation end products (AGEs) effects negatively the aging skin, modifying biochemical, structural, morphological properties skin. study aimed to describe mechanisms AGEs on cells epidermis, dermis, vascular endothelium, w...

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among 500 proteins containing this domain. Although the majority of VWAcontaining proteins are extrace...

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among approximately 500 proteins containing this domain. Although the majority of VWA-containing prote...

In this study, vanillin, a quorum sensing (QS) blocker, and proteinase K were employed to investigate the effect of QS and extracellular proteins on the microbial attachment of aerobic granular activated sludge (AGAS). Results clearly showed that both vanillin and proteinase K could reduce attachment potential of AGAS, and the combined use of them was more effective in reducing attachment bioma...

The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among 500 proteins containing this domain. Although the majority of VWAcontaining proteins are extrace...

Despite being surrounded by diverse nutrients, mammalian cells preferentially metabolize glucose and free amino acids. Recently, Ras-induced macropinocytosis of extracellular proteins was shown to reduce a transformed cell's dependence on extracellular glutamine. Here, we demonstrate that protein macropinocytosis can also serve as an essential amino acid source. Lysosomal degradation of extrace...

Abstract Extracellular matrix (ECM) proteins play a pivotal role in cell growth and differentiation. To characterize aged ECM proteins, we compared the proteomes by shotgun method of young (passage #15) late senescent #40) human dermal fibroblasts (HDFs) using SDS-PAGE coupled with LC–MS/MS. The relative abundance identified was determined mol% individual as semi-quantitative index. Fifteen inc...

Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...

Systemic amyloidosis is a group of diseases associated with extracellular deposition fibrillar proteins, resulting in the loss normal organ structure and function. AL-amyloidosis occurs when amyloid deposited, consisting full-length lambda or kappa immunoglobulin light chains, fragments thereof. This article describes complexity timely diagnosis systemic predominant heart lesion absence myocard...