This study explored the application of 400-DS dissolution apparatus 7 for individual pellet dissolution methodology by a design of experiment approach and compared its capability with that of the USP dissolution apparatus 1 and 2 for differentiating the coat quality of sustained release pellets. Drug loaded pellets were prepared by extrusion-spheronization from powder blends comprising 50%, w/w...

portant component of the mitochondrial respiratory chain (1). Because of its poor aqueous solubility, Coenzyme Q10 (CoQ10) presents a challenge when developing a formulation for oral administration. Many approaches have been used to improve the in vitro dissolution of CoQ10. Some of the approaches include complexation with cyclodextrins (2), preparation of redispersible dry emulsion (3), solid ...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Rectangular waveguide is one of the earliest types of transmission lines. Rectangular waveguide can be produced by hot extrusion process. In this paper, the hot extrusion process of CuZn5 rectangular waveguide was investigated by Finite Element Method (FEM). In addition, Genetic Algorithm (GA) was used to optimize the die geometry and process conditions to achieve the lowest magnitude of extrus...

Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and formulations such as granules, pellets, tablets, supp...

Fabrication of highly dense parts with complex geometry by paste-extrusion-based solid freeform fabrication processes requires a precise control of the extrusion flow rate to dispense material on demand, which is often referred as Extrusion-On-Demand (EOD). The extrusion process for aqueous ceramic pastes is complex and difficult to control due to their non-Newtonian behavior, compressibility a...

This article reviews the infrequently utilized treatment method of forced eruption and how it can serve as an alternative to the sacrifice of the natural root system. Forced eruption can preserve the natural root system and related periodontal architecture, resulting in years of additional service for the patient. It also can maintain adjacent tooth structure while retaining the option for futu...

The production of the pellets in the pharmaceutical industry generally involves multi-step processing; 1 mixing, 2 wet granulation 3 spheronization 4 drying. Tangential spray rotogranulation is now being considered as an alternative since it combines number of steps into one processing unit thus reduces processing time. This work aimed to development and doe analysis of GPCG125 and optimization...