When a young growing eye wears a negative or positive spectacle lens, the eye compensates for the imposed defocus by accelerating or slowing its elongation rate so that the eye becomes emmetropic with the lens in place. Such spectacle lens compensation has been shown in chicks, tree-shrews, marmosets and rhesus monkeys. We have developed a model of emmetropisation using the guinea pig in order ...

DESCRIPTION A 65-year-old man presented with bilateral progressive diminution of vision since the past 2 years. He had loss of vision and pain in the right eye since 2 months. He had no history of acute red eye/trauma/surgery. He had visual acuity of perception of light with accurate projection of rays in the right eye. There was white fluffy material pouring from the lens and settling in the a...

BACKGROUND Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging. METHODS A total of 421 subje...

1. Siew EL, Opalecky D, and Bettelheim FA: Light scattering of normal human lens. II. Age dependence of the light scattering parameters. Exp Eye Res 33:603, 1981. 2. Bettelheim FA: Syneresis and its possible role in cataractogenesis. Exp Eye Res 28:189, 1979. 3. Bettelheim FA and Paunovic M: Light scattering of normal human lens. I. Application of random density and orientation fluctuation theo...

PURPOSE To devise a procedure for direct estimation of corneal oxygen consumption in human subjects. METHODS Tear oxygen tension (PO2) was measured at the posterior surface of two standard hydrogel contact lenses (38% water, 0.2 and 0.06 mm thick, oxygen transmissibility [Dk/t] = 4.2 and 14 x 10(-9) cm x mL O2/mL x sec x torr) and one newly available hydrogel-silicone polymer lens (Dk/t = 99 ...

PURPOSE To test the efficacy of an experimental Dual-Focus (DF) soft contact lens in reducing myopia progression. DESIGN Prospective, randomized, paired-eye control, investigator-masked trial with cross-over. PARTICIPANTS Forty children, 11-14 years old, with mean spherical equivalent refraction (SER) of -2.71 ± 1.10 diopters (D). METHODS Dual-Focus lenses had a central zone that correcte...

Our purpose is to correct digital CCD-recorded Scheimpflug photographs, imaging both the anterior and posterior corneal surface, the anterior chamber, and the anterior eye lens surface for optical distortions. In a ray-tracing algorithm the imaging of the posterior corneal surface in a given Scheimpflug photograph is corrected by applying Snell's law on parallel incident rays entering through t...

PURPOSE To test the possibility that androgen directly affects the corneal cells, the possible occurrence of androgen receptor (AR) in the cornea and other eye tissues of mice was examined. METHODS To examine the occurrence of AR protein in the mouse eye tissues, an immunocytochemical method was used. To examine the occurrence of AR mRNA in the cornea and lens, reverse transcription-polymeras...