Identifying the genes required for environmental sex determination is important for understanding the evolution of diverse sex determination mechanisms in animals. Orthologs of Drosophila orphan receptor Fushi tarazu factor-1 (Ftz-F1) are known to function in genetic sex determination. In contrast, their roles in environmental sex determination remain unknown. In this study, we have cloned and ...

The effect of specific anti-I-J reagents on macrophage-T cell interactions was studied in an in vitro antibody response to burro erythrocytes. Macrophages were prepared from the spleens of F1 hybrid mice whose parental strains differed at the I-J subregion. Two F1 hybrids were used for these experiments, [B10.A(3R) X B10.A(5R)]F1 and [B10.S(9R) X B10.HTT]F1. F1 macrophages responded equally wel...

Previous studies have shown that mucosal application of interleukin-12 (IL-12) can stimulate elevated secretory immunoglobulin A (IgA) responses. Since possible exposure to plague is via Yersinia pestis-laden aerosols that results in pneumonic plague, arming both the mucosal and systemic immune systems may offer an added benefit for protective immunity. Two bicistronic plasmids were constructed...

Sensitive response to low frequency cochlear distortion products in the auditory midbrain. Abstract During auditory stimulation with several frequency components, distortion products (DP) are generated as byproduct of nonlinear cochlear amplification. After generated DP energy is 20 reemitted into the ear channel where it can be measured as distortion product otoacoustic emission (DPOAE) and it...

This paper presents a longitudinal analysis of the extent to which age affects F0 and formant frequencies. Five speakers at two time intervals showed a clear effect for F0 and F1 but no systematic effects for F2 or F3. In two speakers for which recordings were available in successive years over a 50 year period, results showed with increasing age a decrease in both F0 and F1 for a female speake...

To investigate the possible enhancing effect of the H-2z haplotype of the New Zealand White (NZW) strain on the production of autoantibodies and renal disease observed in B/W F1 mice, we developed the ZWD/8 strain, a NZW congenic line carrying the H-2d haplotype, produced (NZB X ZWD/8)F1 (B/WD8 F1) mice, and examined the difference in several immunological abnormalities between the B/W F1 (H-2d...