Purple corn is a cereal plant that has health benefits. contains anthocyanins, which are useful as anticancer and antioxidants, high nutritional value. Improving the quality of production can be done through breeding. This study aimed to determine value variability, heritability expected genetic advance F3 purple from open-pollinated hybridization. The research was conducted December 2020 April...

Abstract Flavonoids, such as anthocyanins, proanthocyanidins, and flavonols, are widespread plant secondary metabolites important for adaptation to diverse abiotic biotic stresses. Flavonoids can be variously hydroxylated decorated; their biological activity is partly dependent on the degree of hydroxylation B-ring. Flavonoid biosynthesis regulated by MYB transcription factors, which have been ...

Daun sirsak (Annona muricata L.) mengandung flavonoid yang memiliki aktivitas antioksidan sangat kuat . Telah dibuat formula handbody lotion daun masing-masing 0,05% (F1), 0,1% (F2), 0,15% (F3). Tujuan penelitian ini untuk melihat dari ketiga ekstrak etanol (F1, F2, F3) telah dibuat.Uji dilakukan terhadap F1, dan F3 menggunakan metode DPPH dengan menentukan nilai IC 50 formula. Hasil menunjukka...

Mcl-1 is a member of the Bcl-2 family protein; its degradation is required for the initiation of apoptosis. The mechanism, however, is not yet clearly known. Previously, it was reported that Mcl-1 is degraded through the ubiquitination-mediated pathway and the PEST domain is the motif responsible for promoting this degradation. We found evidence that this may not be true. We generated several M...

Melastoma malabathricum Linn. is a perennial traditional medicine plants that grows abundantly throughout Asian countries. In this study, M. malabathricum Linn. leaf hot water crude extract with anticoagulant activity was purified through solid phase extraction cartridge and examined for the bioactive chemical constituents on blood coagulation reaction. The SPE purified fractions were, respecti...

BACKGROUND Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown. OBJECTIVES We tested the hypothesis that the ultrafine fraction of ambient pollutant particles would cause endothelial cell dysfunction. METHODS We profiled gene expression of human pulmonary artery endothelial cells (HPAEC) expo...

Mahamrutyunjaya rasa (MHR), an Ayurvedic formulation, used as cardiotonic, contains potentially toxic compounds like aconitine, which are detoxified during preparation using traditional methods. Comparative toxicological evaluation of laboratory prepared formulation (F1) and two marketed formulations (F2 and F3) were performed based on their effects on viability of H9c2 cells and after single o...

OBJECTIVE To study the acoustic features of the patients with congenital velopharyngeal insufficiency (CVPI). METHODS The acoustic features of 28 patients with CVPI were analyzed with the computer speech lab, contrasted by the features of 20 controls. RESULTS There was significant difference in F2, B2, F3, B3 and VOT between the patients and the controls (P<0.05). It was not same on every s...

In a previous study, we have shown that human neural stem cells (hNSCs) transplanted in brain of mouse intracerebral hemorrhage (ICH) stroke model selectively migrate to the ICH lesion and induce behavioral recovery. However, low survival rate of grafted hNSCs in the brain precludes long-term therapeutic effect. We hypothesized that hNSCs overexpressing Akt1 transplanted into the lesion site co...

Iron regulatory proteins (IRPs) are cytoplasmic RNA binding proteins that are central components of a sensory and regulatory network that modulates vertebrate iron homeostasis. IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5' or 3' untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Two IRPs, IRP1 and IRP2, have been identified previously....