normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 the maxillary lateral incisor is the second most common congenitally absent tooth. there are several treatment options for replacing the missing maxillary lateral incisor, including canine substitution, tooth-supported restoration, or single-tooth implant. dental implants are an appropriate treatment option for replacing m...

Advances in detection technologies have enabled an increased use of cell-based functional assays in early drug discovery, in particular for G protein-coupled receptors. Screening assays that use live cells are less prone to generate false positives than assays using lysed cell samples. The use of cryopreserved cells instead of cells that are continuously maintained in culture decreases day-to-d...

T racheoesophageal puncture (TEP) is the preferred method for voice restoration following total laryngectomy. While several techniques for secondary puncture have been described, most require general anesthesia or intravenous sedation. Techniques for in-office, unsedated secondary TEP have been developed but are limited due to patient discomfort, inability to maintain direct visualization of th...

Abstract We study the statistical properties of first-passage time functionals a one dimensional Brownian motion in presence stochastic resetting. A functional is defined as V = ∫...

Label-free quantification of shotgun LC-MS/MS data is the prevailing approach in quantitative proteomics but remains computationally nontrivial. The central data analysis step is the detection of peptide-specific signal patterns, called features. Peptide quantification is facilitated by associating signal intensities in features with peptide sequences derived from MS2 spectra; however, missing ...

This paper derives physically meaningful boundary conditions for fractional diffusion equations, using a mass balance approach. Numerical solutions are presented, and theoretical properties are reviewed, including well-posedness and steady state solutions. Absorbing and reflecting boundary conditions are considered, and illustrated through several examples. Reflecting boundary conditions involv...

Introduction: Echo planar images (EPI) are applied in a variety of diagnostic techniques that rely on fast acquisition of imaged data. EPI applications in common practice range from dynamic-contrast studies used to monitor the passage of injected contrast over time for stroke, tumor evaluation, and cardiac assessment to fMRI applications where a large series of images (typically thousands) are ...

Accurate assignment of peptide sequences to observed fragmentation spectra is hindered by the large number of hypotheses that must be considered for each observed spectrum. A high score assigned to a particular peptide-spectrum match (PSM) may not end up being statistically significant after multiple testing correction. Researchers can mitigate this problem by controlling the hypothesis space i...

BACKGROUND Most protein mass spectrometry (MS) experiments rely on searches against a database of known or predicted proteins, limiting their ability as a gene discovery tool. RESULTS Using a search against an in silico translation of the entire human genome, combined with a series of annotation filters, we identified 346 putative novel peptides [False Discovery Rate (FDR)<5%] in a MS dataset...