Currently, no pharmacological therapies treat skeletal muscle insulin resistance in pathological conditions such as type 2 diabetes, age-associated diseases, and cancer. Therefore, there is an unmet need to identify the molecular mechanisms ...The events governing glucose uptake have potential for managing obesity, With current treatments target ...

AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that has been thought to be an important mediator for exercise-stimulated glucose uptake in skeletal muscle. Liver kinase B1 (LKB1) is an upstream kinase for AMPK and AMPK-related protein kinases, of which the function in skeletal muscle has not been well documented. Our group and others have generated mice lacking AMPK activity in skeleta...

Functional micropeptides can be concealed within RNAs that appear to be noncoding. We discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncoding RNA. MLN shares structural and functional similarity with phospholamban (PLN) and sarcolipin (SLN), which inhibit SERCA, the membrane pump that controls muscle ...

Muscle contraction and insulin induce glucose uptake in skeletal muscle through GLUT4 membrane translocation. Beneficial effects of exercise on glucose homeostasis in insulin-resistant individuals are known to be due to their distinct mechanism between contraction and insulin action on glucose uptake in skeletal muscle. However, the underlying mechanisms are not clear. Here we show that in skel...

BACKGROUND At fluorodeoxyglucose/positron emission tomography (FDG/PET) examinations, a generally increased uptake of the skeletal muscles is sometimes encountered. As the tracer distribution constitutes a 'zero-sum-game', the uptake of lesions as well as of normal tissues is reduced in these patients. This has to be considered at calculation of standardised uptake values (SUVs), especially at ...

DESCRIPTION A 54-year-old patient underwent right radical nephrectomy for what was then diagnosed as a Stage-II (T2bN0M0) renal cell carcinoma (RCC). Four months after surgery, the patient reported of pelvic pain and had a rising serum alkaline-phosphatase level. The tecnetium-99 mmethylene-diphosphate (Tc99m-MDP) bone scan then demonstrated a focus of uptake in the right ischium, corresponding...

OBJECTIVE We have previously shown in humans that local infusion of a nitric oxide synthase (NOS) inhibitor into the femoral artery attenuates the increase in leg glucose uptake during exercise without influencing total leg blood flow. However, rodent studies examining the effect of NOS inhibition on contraction-stimulated skeletal muscle glucose uptake have yielded contradictory results. This ...

Ho, Richard C., Oscar Alcazar, Nobuharu Fujii, Michael F. Hirshman, and Laurie J. Goodyear. p38 MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol 286: R342–R349, 2004. First published October 30, 2003; 10.1152/ ajpregu.00563.2003.—Skeletal muscle expresses at least three p38 MAPKs ( , , ). Howeve...

UNLABELLED (18)F-FDG and (18)F-FDG-labeled white blood cells ((18)F-FDG-WBCs) are valuable radiopharmaceuticals for imaging focal sites of inflammation and infection. In the present study, the imaging properties of both radiotracers were compared in sterile and septic inflammation models. METHODS Groups of adult male Sprague-Dawley rats (100-120 g) were injected in the left posterior thigh mu...