BACKGROUND Previous studies indicated that the iron (Fe)/manganese (Mn) ratio in forage of sheep was significantly higher on scrapie-afflicted farms than on farms in other scrapie categories. This study was conducted to examine whether Fe and Mn in forage of sheep varied in general according to the scrapie status of different areas in the country. Copper (Cu) and zinc (Zn) were also included be...

Iron (Fe) is an essential trace metal involved in numerous cellular processes. Iron deficiency (ID) is reported as the most prevalent nutritional problem worldwide. Increasing evidence suggests that ID is associated with altered neurotransmitter metabolism and a risk factor for manganese (Mn) neurotoxicity. Though recent studies have established differences in which the female brain responds to...

The Fe- and Mn-containing superoxide dismutases catalize the same reaction and have almost superimposable active sites. Therefore, the details of their mechanisms have been assumed to be similar. However, we now show that the pH dependence of Escherichia coli MnSOD activity reflects a different active site proton equilibrium in (oxidized) Mn(3+)SOD than the event that affects the active site pK...

Background: Unsafe food consumption is a severe problem because of heavy metal contamination, which is caused by director indirect activities of industries. The present study was conducted to assess the risk of human health by Heavy metals (Cu, Co, Fe, Zn and Mn) through the intake of vegetables and fishes obtained from the area adjacent to the Hazaribag tannery campus, Dhaka, Bangladesh. Resul...

Bacillus anthracis is a severe mammalian pathogen encoding a class Ib ribonucleotide reductase (RNR). RNR is a universal enzyme that provides the four essential deoxyribonucleotides needed for DNA replication and repair. Almost all Bacillus spp. encode both class Ib and class III RNR operons, but the B. anthracis class III operon was reported to encode a pseudogene, and conceivably class Ib RNR...

Determinou-se a bioacessibilidade de Ca, Mg, Mn e Fe em infusões de café em pó através de digestão gastrointestinal in vitro com soluções de suco estomacal e intestinal (pepsina, pancreatina e sais biliares). A absorção de metais nas vilosidades intestinais foi simulada por ultrafiltração com uma membrana semi-permeável de 3 kDa de massa molar de corte. As concentrações de Ca, Fe, Mg e Mn em in...

We have recently shown that Deinococcus radiodurans and other radiation resistant bacteria accumulate exceptionally high intracellular manganese and low iron levels. In comparison, the dissimilatory metal-reducing bacterium Shewanella oneidensis accumulates Fe but not Mn and is extremely sensitive to radiation. We have proposed that for Fe-rich, Mn-poor cells killed at radiation doses which cau...

A study was designed to evaluate the micronutrients status of soils of district Palandri, Azad Kashmir and to correlate the micronutrients with Physico-chemical characteristics of soil as well as to categorize the soils as high, medium and low in Cu, Zn, Fe, Mn and HWS B. Soil samples were collected from thirty wheat fields and thirty apple orchard soils during 2003. None of the soil sample was...

Fe and Mn are both entrained to the same chemical reaction in apparently superimposable superoxide dismutase (SOD) proteins. However, neither Fe-substituted MnSOD nor Mn-substituted FeSOD is active. We have proposed that the two SOD proteins must apply very different redox tuning to their respective metal ions and that tuning appropriate for one metal ion results in a reduction potential (E(m))...