The maturation of inhibitory transmission through γaminobutyric acid (GABA) is required to induce ocular dominance (OD) plasticity in the visual cortex. However, only circuits that are mediated by specific GABAA receptors can selectively elicit OD plasticity, implying a role of local circuits involved in GABA inhibition in this process. In this study, in order to theoretically examine the effec...

Olfactory cortex pyramidal cells integrate sensory input from olfactory bulb mitral and tufted (M/T) cells and project axons back to the bulb. However, the impact of cortical feedback projections on olfactory bulb circuits is unclear. Here, we selectively express channelrhodopsin-2 in olfactory cortex pyramidal cells and show that cortical feedback projections excite diverse populations of bulb...

The Rhodococcus erythropolis (strain IGTS8) bacterium has a tremendous industrial interest as it can remove sulfur from crude oil through its four-enzyme (DszA-D) 4S metabolic pathway. DszC is one of the rate-limiting enzymes pathway and that most suffers feedback inhibition. We have combined molecular docking dynamics simulations to identify binding sites which two products pathway, 2-hydroxyb...