Biological systems are often subject to external noise from signal stimuli and environmental perturbations, as well as noises in the intracellular signal transduction pathway. Can different stochastic fluctuations interact to give rise to new emerging behaviors? How can a system reduce noise effects while still being capable of detecting changes in the input signal? Here, we study analytically ...

With the introduction of commercially available amplifiers using the current feedback topology by Comlinear Corporation in the early 1980’s, previously unattainable gain and bandwidths in a DC coupled amplifier became easily available to any design engineer. The basic achievement realized by the current feedback topology is to de-couple the signal gain from the loop gain part of the overall tra...

An optimization approach to control reconnguration, based on eigenstructure assignment , for control systems with output feedback is presented. The emphasis is on the recovery of the nominal closed-loop performance, which is determined by the closed-loop eigenvalues and eigenvectors. The proposed scheme preserves the max(r; q) most dominant eigenvalues of the nominal closed-loop system and dete...

In this paper, control of a non-isothermal continuous stirred tank reactor in which two parallel autocatalytic reactions take place has been addressed. The reactor shows chaotic behavior for a certain set of reactor parameters. In order to control the product concentration, an optimal state feedback controller has been designed. Since concentrations of reactor species are ...

Brain state regulates sensory processing and motor control for adaptive behavior. Internal mechanisms of brain state control are well studied, but the role of external modulation from the environment is not well understood. Here, we examined the role of closed-loop environmental (CLE) feedback, in comparison to open-loop sensory input, on brain state and behavior in diverse vertebrate systems. ...

Feedback controls are central to cellular regulation. Negative-feedback mechanisms are well known to underline oscillatory dynamics. However, the presence of multiple negative-feedback mechanisms is common in oscillatory cellular systems, raising intriguing questions of how they cooperate to regulate oscillations. In this work, we studied the dynamical properties of a set of general biochemical...