DNA polymerases can misinsert ribonucleotides that lead to genomic instability. DNA polymerase β discourages ribonucleotide insertion with the backbone carbonyl of Tyr-271; alanine substitution of Tyr-271, but not Phe-272, resulted in a >10-fold loss in discrimination. The Y271A mutant also inserted ribonucleotides more efficiently than wild type on a variety of ribonucleoside (rNMP)-containing...

Multipoint competition refers to situations in which firms meet the same rivals in many markets, which may lead to a reduction of competitive pressure. Indeed, a high number of multipoint contacts between two rivals provides many footholds in each other’s strategic territories – called spheres of influence increasing the deterrents to attack.,This situation is known under Mutual Forbearance (MF...

Secondary metabolites from Dysoxylum malabaricum and Dysoxylum beddomei were tested against mature and immature stage of the mosquito vector Anopheles stephensi under laboratory conditions. The triterpenes 3beta,24,25-trihydroxycycloartane and beddomeilactone from D. malabaricum and D. beddomei showed strong larvicidal, pupicidal and adulticidal activity. They also affected the reproductive pot...

abstract background: premature neonates’ feeding is of great importance due to its effective role in their growth. these neonates should reach an independent oral nutrition stage before being discharged from the neonatal intensive care unit. therefore, the researcher decided to conduct a study on the effect of palady and cup feeding on premature neonates’ weight gain and their reaching full ora...

To illustrate the implementation of a bottom-up approach to the study of culture in health disparities, this article describes the development of a cultural cancer screening scale (CCSS) using mixed methodologies. The aim was to identify cultural factors relevant to breast and cervical cancer screening, develop an instrument to assess them and examine its preliminary psychometric properties amo...