The present research was designed to evaluate different matrix, drug-in-adhesive and reservoir formulations of fentanyl transdermal patches. The target was to design drug-in-adhesive patches (DIAPs); a full factorial design was used. Different types and amounts of liquid, pressure-sensitive adhesives (PSAs) were used and evaluated with respect to drug release and adhesive properties. A very sim...

Transdermal scopolamine and transdermal placebo patches were administered on alternating days to 12 normal volunteer subjects. Visual near-point values and self-reports of blurred vision were systematically assessed 24 hours following each transdermal patch. Blurred vision was not reported following the first scopolamine patch, but became increasingly frequent following successive scopolamine p...

Spatiotemporal and interspecies irregularities in planktonic populations have been widely observed. Much research into the drivers of such plankton patches has been initiated over the past few decades but only recently have the dynamics of the interacting patches themselves been considered. We take a coupled lattice approach to model continuous-in-time plankton patch dynamics, as opposed to the...

Fentanyl, a surgical analgesic and general anaesthetic, is a lipophilic short-acting synthetic opioid, having a selective potent effect on mu receptors. The transdermal therapeutic fentanyl-system (TTS-F) allows for a continued and sustained titratable amount of fentanyl to be delivered without the inconvenience of the typical 24-h administration of other analgesics. Although incidences of resp...

insulin-loaded biodegradable chitosan nanoparticle was prepared by the polyelec-trolyte complex formation method. the prepared nanoparticles were in the size of 110 nm and had high entrapment (91.0%) capacity. the transdermal nanoinsulin was characterized by in vivo hypoglycemic effects. plasma glucose was decreased to the range of 80.34 to 96.74 mg/dl, and insulin levels were increased to the ...

Purpose. Fentanyl is available as a transdermal system for the treatment of chronic pain in opioid-tolerant patients; however, it carries a black box warning due to both the potency of the product and the potential for abuse. In this report, we describe a case of transbuccal and gastrointestinal ingestion of fentanyl patches and the management of such ingestion. Summary. A 32-year-old man was b...

the present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (pvp) and ethyl cellulose (ec) using a d-optimal mixture design. the prepared transdermal patches were subjected to different physicochemical evaluation. the surface topography of the patches was examined by scanning electron microscopy (s...