In this study, we examined and compared two different lipid-based nanosystems (LBNs), namely Transferosomes (TFs) Monoolein Aqueous Dispersions (MADs), as delivery systems for the topical application of Ferulic Acid (FA), an antioxidant molecule derived from natural sources. Our results, demonstrated through Franz-cell experiments, indicate that LBNs produced with poloxamer 188 in their composi...

Abstract Ferulic acid ( p -hydroxy-3-methoxycinnamic acid, FA) is a natural active substance present in plant cell walls, with antioxidant, anticancer, antithrombotic and other properties; it widely used medicine, food, cosmetics. Production of FA by eco?friendly bioprocess great potential. In this study, was biosynthesized metabolically engineered Escherichia coli . As the first step, genes ta...

Ferulic acid is known to act as a protective agent in cerebral ischemia through its anti-oxidant activity. γ-Enolase is a neuron-specific enolase that also exerts a neuroprotective effect. Here, we investigated whether ferulic acid regulates the expression level of γ-enolase in middle cerebral artery occlusion (MCAO)-induced brain injury and glutamate exposure-induced neuronal cell death. Adult...

Ginseng extract (GE), ferulic acid (≥99%) (FA), and a fermented noni juice powder (FNJP) were analyzed for their antioxidant antimicrobial activities in vitro. Half inhibitory concentration (IC50) was 29.87, 0.45, 3.82 mg/mL, GE, FA, FNJP, respectively. The potential of the three extracts to inhibit polyphenol oxidase from vegetable matrices ranged between no inhibition 95.1% (depending on PPO ...

Amyloid precursor protein (APP) proteolysis is required for production of amyloid-β (Aβ) peptides that comprise β-amyloid plaques in brains of Alzheimer's disease (AD) patients. Recent AD therapeutic interest has been directed toward a group of anti-amyloidogenic compounds extracted from plants. We orally administered the brain penetrant, small molecule phenolic compound ferulic acid (FA) to th...

The aim of this study is to investigate the effects of dietary supplementation with the Driselase-treated fraction (DF) of rice bran and ferulic acid (FA) on hypertension and glucose and lipid metabolism in stroke-prone spontaneously hypertensive rats (SHRSP). Male SHRSP at 4 weeks of age were divided into three groups, and for 8 weeks were fed (1) a control diet based on AIN-93M, (2) a DF of r...

A molecular marker compound, derived from lignin by the thioacidolysis degradative method, for structures produced when ferulic acid is incorporated into lignin in angiosperms (poplar, Arabidopsis, tobacco), has been structurally identified as 1,2,2-trithioethyl ethylguaiacol [1-(4-hydroxy-3-methoxyphenyl)-1,2,2-tris(ethylthio)ethane]. Its truncated side chain and distinctive oxidation state su...

Ferulic acid is released by microbial hydrolysis in the colon, where butyric acid, a major by-product of fermentation, constitutes the main energy source for colonic enterocytes. We investigated how varying concentrations of this short chain fatty acid may influence the absorption of the phenolic acid. Chronic treatment of Caco-2 cells with butyric acid resulted in increased mRNA and protein ab...

In this work the possibility of producing vanillin through microbial bioconversion from ferulic acid obtained from the enzymatic hydrolysis of wheat bran has been explored. The biocatalyst employed was Escherichia coli JM109/pBB1, a recombinant strain containing the genes from Pseudomonas fluorescens BF13 for the transformation of ferulic acid into vanillin. The substrate of the bioconversion, ...

During the brewing process, lipid oxidation can lead to undesirable flavours in beer [I]. Naturally occuring phenols in malt (germinated barley) have proven their effectiveness as antioxidants [2]. Ferulic acid (4-hydroxy-3methoxy cinnamic acid) is the most abundant phenolic acid in barley. It acccounts for 0.14% of dry matter in barley grains 131, and it is mainly esterified to arabinofuranosy...