Both low birth weight and excessive fetal weight at delivery are associated with an increased risk of newborn complications during labor and the puerperium. The perinatal complications associated with low birth weight are attributable to preterm delivery, intrauterine growth restriction (IUGR), or both. For excessively large fetuses, the potential complications associated with delivery include ...

Introduction Preeclampsia is the first cause of maternal morbidity and mortality, intrauterine growth retardation (IUGR), and fetal prematurity (Abdel Razik, 2016). Preeclampsia affects 5-10% of pregnancies and is clinically manifested after 20 weeks of gestation. Fetal hypoxemia caused by preeclampsia can lead to ischemic encephalopathy, growth retardation, and various sequalae of premature bi...

An analysis of antepartum, intrapartum, and postpartum variables was performed in a retrospective controlled study of 34 normally formed term infants who had perinatal asphyxia and subsequently displayed generalised seizures within 48 hours of birth. The aim was to identify any association, firstly between these variables and seizures, and secondly between these variables and subsequent morbidi...

Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an inhibitor of the prooxidant enzyme xanthine oxidase. Here, we established in a rodent model the capacity of allopurinol to be taken up by the mother, cross the placenta, rise to therapeutic levels...