BACKGROUND AND OBJECTIVES During fetal development a change in erythropoiesis from hepatic to medullary site occurs. In chromosomally abnormal fetuses this change is delayed. Hemoglobin production also undergoes developmental switches from embryonic to fetal hemoglobins in the first trimester of pregnancy. The aim of study was to determine the proportion of embryonic and fetal hemoglobins in fe...

BACKGROUND β-thalassemia considers worldwide public health disorders. Novel fetal hemoglobin inducer agents such as thalidomide and sodium butyrate have been attended for ameliorating clinical complications of such disorders. MATERIAL AND METHODS We used thalidomide and sodium butyrate for increasing the level of fetal hemoglobin in erythroid progenitors. Briefly, after isolation of CD133+ st...

To determine whether hemoglobin regulation is normal in diseases affecting 1-globin gene expression. globin synthesis was examined in members of a family of a patient with hereditary persistence of fetal hemoglobin/fi#{176}-thalassemia (HPFH/$#{176}-thal). The HPFH defect is the Ghanian type II. with a deletion from t’$ to at least 20 kb 3’ to . The / #{176}-thaI gene has the haplotype II restr...

A 39-year-old 34-week-pregnant woman was referred to our hospital for preterm labor and fetal dysfunction. Fetal middle cerebral artery systolic maximum blood flow velocity was high, so fetal anemia was suspected. Blood type was O-type Rh (+) and fetal hemoglobin was 0.4%; tests for irregular antibody and human parvovirus B19 IgM were negative. A high brightness echoic mass was observed in feta...

The "alkaline haematin D-575" method for determining haemoglobin, described by Zander et al. [1984) Clin. Chim. Acta 136, 83-93) was tested. Claims that different non-ionic detergents in the reagent result in identical values for the haemoglobin concentration being measured could not be verified. It could also not be verified that a stable end-product with unique spectral characteristics is alw...

Sickle cell disease is the most common inherited hemoglobinopathy associated with adverse maternal and fetal outcomes. It often diagnosed at an early age. Presentation for first time in pregnancy as leucoerythroblastosis rare. Diagnosis requires a strong suspicion demonstration of hemoglobin S blood.

Several methods have been developed for the estimation of foetal haemoglobin levels by alkali denaturation (Singer, Chernoff, and Singer, 1951; Betke, Marti, and Schlicht, 1959; Kristoffersen, 1961) but there have been increasing demands for a simple method which is sensitive enough to measure reproducibly small elevations of foetal haemoglobin in both inherited and acquired haematological diso...