The correlation between hereditary thrombophilia and fetal loss is supported by several observations. In murine models, the protein C system has been shown to be essential for the maintenance of pregnancy, as it indirectly acts as a growth factor for trophoblast cells and protects them from apoptosis. In humans, it has been shown that the placenta replaces the yolk sac as an essential source of...

Healthy pregnancy depends on proper placentation-including proliferation, differentiation, and invasion of trophoblast cells-which, if impaired, causes placental ischemia resulting in intrauterine growth restriction and preeclampsia. Mechanisms regulating trophoblast invasion, however, are unknown. We report that reduction of Inverted formin 2 (INF2) alters intracellular trafficking and signifi...

Fetal wastage is still high in the pregnancies of patients with systemic lupus erythematosus (SLE). We examined retrospectively the cases of 38 patients with inactive SLE in whom pregnancy was either desired or had already been obtained. The prevalence of antiphospholipid antibodies in the group with fetal loss was high. The antibodies were, however, also detected in five of 14 patients who had...

OBJECTIVE The aim of this study was to investigate risk factors for placental abruption and to determine if anamnestic variables such as inherited thrombosis or recurrent fetal loss might be used as a predictor for placental abruption. METHODS A retrospective case-control study at the University Hospital, Palacky University, Olomouc, Czech Republic. One hundred and eighty women with placental...

Fetal loss induced by antiphospholipid antibodies (aPLs) in mice is a complement-driven inflammatory condition. Engagement of the complement receptor C5aR on neutrophils induces expression of the principal initiator of the blood clotting mechanism, tissue factor (TF), and blocking this downstream event of complement activation prevents antibody-induced fetal loss. In this issue of the JCI, the ...

Results The prevalence of various pregnancy complications was 8. 6% for birth prematurely, 9. 2% for hypertension or preeclampsia, IUGR 5. 8% and 7. 3% for loss pregnancy. PAPP A levels were lower in fetal loss group (P = 0. 005), vascular disease group(P = 0. 001) and preterm delivery group(P = 0. 001). In addition, a lower rate of bHCG was associated with the occurrence of placental pathologi...

Defective placentation and subsequent placental insufficiency lead to maternal and fetal adverse pregnancy outcome, but their pathologic mechanisms are unclear, and treatment remains elusive. The mildly hypertensive BPH/5 mouse recapitulates many features of human adverse pregnancy outcome, with pregnancies characterized by fetal loss, growth restriction, abnormal placental development, and def...

Background: To evaluate the association of increased fetal nuchal translucency( NT) and adverse pregnancy outcomes. Materials and Methods: In a prospective study, 2221 women who were conceived after Assisted Conception were investigated by sonography independent of multiplicity between 11 and 13 weeks' gestation. We performed 2899 NT examinations during the study period(21 March 2010 to 21...

OBJECTIVES Women have increased risks of severe mental disorders after childbirth and death of a child, but it remains unclear whether this association also applies to fetal loss and, if so, to which extent. We studied the risk of any inpatient or outpatient psychiatric treatment during the time period from 12 months before to 12 months after fetal death. DESIGN Cohort study using Danish popu...

Vamshadeepa.N Asst. professor, Department of BME, ACSCE, Bangalore [email protected] Priyanka.H.B Student, Department of BME, ACSCE, Bangalore [email protected] Ashwini.V Student, Department of BME, ACSCE, Bangalore [email protected] -----------------------------------------------------------Abstract---------------------------------------------------------------------------...