نتایج جستجو برای: fgfr4 gene

تعداد نتایج: 1141581  

Journal: :Cell metabolism 2014
Shuangwei Li Diane D F Hsu Bing Li Xiaolin Luo Nazilla Alderson Liping Qiao Lina Ma Helen H Zhu Zhao He Kelly Suino-Powell Kaihong Ji Jiefu Li Jianhua Shao H Eric Xu Tiangang Li Gen-Sheng Feng

Bile acid (BA) biosynthesis is tightly controlled by intrahepatic negative feedback signaling elicited by BA binding to farnesoid X receptor (FXR) and also by enterohepatic communication involving ileal BA reabsorption and FGF15/19 secretion. However, how these pathways are coordinated is poorly understood. We show here that nonreceptor tyrosine phosphatase Shp2 is a critical player that couple...

Journal: :BPB reports 2021

Cadmium (Cd) is an environmental hazardous heavy metal that causes renal dysfunction triggered by its toxicity to proximal tubular cells. Our previous study demonstrated Cd changed the activities of various transcription factors (TFs) in mouse kidney. In this study, we investigated whether long-term exposure affected expression levels downstream genes these TFs. C57BL/6J female mice were fed ch...

Journal: :Frontiers in animal science 2022

Several studies on the role of HCA species in regulating glucose homeostasis have indicated their therapeutic value human obesity and diabetes. There is a clear difference percentage hyocholic acid (HCA) its derivatives (also known as species) total bile (BA) pool plasma between humans, rats pigs. However, gut microbiota BA profiles pigs remains unclear. We generated five germ-free pig models s...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Li Tan Jun Wang Junko Tanizaki Zhifeng Huang Amir R Aref Maria Rusan Su-Jie Zhu Yiyun Zhang Dalia Ercan Rachel G Liao Marzia Capelletti Wenjun Zhou Wooyoung Hur NamDoo Kim Taebo Sim Suzanne Gaudet David A Barbie Jing-Ruey Joanna Yeh Cai-Hong Yun Peter S Hammerman Moosa Mohammadi Pasi A Jänne Nathanael S Gray

The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or from up-regulation of compensatory signaling pathways. Preclinical studies have demonstrated that resistance to FGFR inhibitors can be ac...

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