BACKGROUND/AIMS To study the initial characteristics and response to intravitreal ranibizumab (IVR) treatment of age-related macular degeneration (AMD). METHODS We reviewed the clinical records of 141 eyes in 141 AMD patients who received monthly IVR for 3 months and thereafter pro re nata (PRN) injections for 9 months as the first treatment for AMD. Patients whose best corrected visual acuit...

Purpose To investigate timing and risk factors of recurrent retinopathy of prematurity (ROP) after intravitreal ranibizumab (IVR) monotherapy. Methods Fifty eyes (the more severe eye) of 50 infants treated with IVR monotherapy for type 1 ROP were studied retrospectively. The mean follow-up time was 31 weeks after IVR. Recurrent ROP (recurrence of extraretinal fibrovascular proliferation [EFP]...

Inflammatory endobronchial polyp is a rare disease mostly encountered in asthmatic patients. Chronic airway and foreign material irritation or thermal injury may result in the formation of granulated tissues and become polypoid mass. Herein, we describe a 52-year-old man with severe respiratory distress and infection with 35 years history of smoking. He had an obstructive pattern in his pulmona...

OBJECTIVE To characterize histopathologic features of leaking mitomycin C-treated blebs and aberrant wound healing that may lead to persistent conjunctival thinning and leakage. METHODS Forty mitomycin C-treated filtering blebs excised for persistent leaks from 40 patients were examined histopathologically using hematoxylin-eosin, periodic acid-Schiff, Masson trichrome, and Alcian blue histoc...

AIMS To determine the presence and origin of myofibroblasts in pterygia. METHODS 86 specimens including head, body, and fibrovascular tissue from 52 primary and 34 recurrent pterygia and five exenterated eyes without pterygia were searched for the origin of myofibroblasts. All tissues were subjected to haematoxylin and eosin staining, immunohistochemistry using antibodies against alpha smooth...

PURPOSE To evaluate the local safety of bevacizumab and its effect on recurrence of primary pterygium excision. METHODS This randomized, placebo-controlled clinical trial was conducted on 44 eyes of 44 patients randomized to Group 1 (bevacizumab) and Group 2 (balanced salt solution). Group 1 underwent pterygium excision with a rotational conjunctival flap and received a total of 7.5 mg subcon...

the gastric inflammatory fibroid polyp (ifp) is a rare benign tumor of unknown etiology that is localized mainly in the antrum and presents endoscopically as submucosal mass. the lesion manifests as abdominal pain, weight loss, bleeding, dyspeptic symptoms, and iron deficiency anemia. we report a case of gastric ifp presented with microcytic anaemia, dyspepsia, malena and weight loss. endoscopy...

Eukaryotes contain inorganic polyphosphate (polyP) and acidocalcisomes, which sequester polyP and store amino acids and divalent cations. Why polyP is sequestered in dedicated organelles is not known. We show that polyP produced in the cytosol of yeast becomes toxic. Reconstitution of polyP translocation with purified vacuoles, the acidocalcisomes of yeast, shows that cytosolic polyP cannot be ...

This study was designed to explore the prevalence of fibrovascular proliferation not regressed in zone II stage 3 retinopathy of prematurity (ROP) after initial intravitreal ranibizumab (IVR) injections and to explore the possible influence factors. Fifty-seven patients (108 eyes) with ROP who underwent intravitreal injection of ranibizumab between January 2013 and July 2014 participated in the...