Abs t rac t . A novel anaphase block phenotype was found in fission yeast temperature-sensitive cut9 mutants. Cells enter mitosis with chromosome condensation and short spindle formation, then block anaphase, but continue to progress into postanaphase events such as degradation of the spindle, reformation of the postanaphase cytoplasmic microtubule arrays, septation, and cytokinesis. The cut9 m...

The DNA integrity checkpoints ensure completion of DNA replication and DNA repair before entry into mitosis (O’Connell et al., 2000). Unreplicated DNA or unrepaired DNA will cause catastrophic chromosome segregation. The accompanying schematic shows the checkpoint proteins that monitor the state of DNA replication and DNA repair. Checkpoint proteins most probably interact with the replication c...

ABSTRACT First Person is a series of interviews with the first authors selection papers published in Journal Cell Science, helping early-career researchers promote themselves alongside their papers. Keiichiro Sakai author on ‘ Near-infrared imaging fission yeast using genetically encoded phycocyanobilin biosynthesis system’, JCS. PhD student lab Kazuhiro Aoki at Quantitative Biology Research Gr...

Yeast Dnm1p is a soluble, dynamin-related GTPase that assembles on the outer mitochondrial membrane at sites where organelle division occurs. Although these Dnm1p-containing complexes are thought to trigger constriction and fission, little is known about their composition and assembly, and molecules required for their membrane recruitment have not been isolated. Using a genetic approach, we ide...