DuBell, W. H., W. J. Lederer, and T. B. Rogers. K1 currents responsible for repolarization in mouse ventricle and their modulation by FK-506 and rapamycin. Am. J. Physiol. Heart Circ. Physiol. 278: H886–H897, 2000.—Modulation of mouse ventricular action potentials and K1 currents was examined using the whole cell patch-clamp technique. The composite mouse ventricular K1 current (consisted of an...

The effects of the immunosuppressive drugs cyclosporin A and FK 506 were studied on cells chronically infected with human immunodeficiency virus type 1 (HIV-1) as well as on uninfected and newly infected cells. When cells chronically infected with HIV-1 or with HIV-2 were cocultivated with uninfected cells in the presence of cyclosporin A or FK 506 there was a delay in the formation of syncytia...

I N initial clinical trials of organ transplanta.tion, F~. 5~ has shown remarkable immunosuppressive activity. The drug is very lipophilic. metabolized in the liver, and predominantly eliminated through the bile. 2 Hepatic dysfunction was expected to alter the pharmacokinetics of FK 506. Hepatic dysfunction is also known to alter the absorption of lipid soluble drugs. 3 This is related to the l...

ACUTE graft-versus-host disease (GVHD) is a systemic manifestation of activation of normal allodisparate transplanted lymphoid cells to recipient epithelial target organs. In clinical bone marrow transplantation (BMT) between HLA identical siblings, acute GVHD occurs in up to 50% of cases, 1 many times during the early posttransplant period. It has recently been shown that FK 506 is superior to...

OBJECTIVE To study the effects of different disease-modifying antirheumatic drugs (DMARD) on different events mediated by IL-15-activated lymphocytes. METHODS Peripheral blood lymphocytes (PBL) were isolated from healthy donors and activated with IL-15 after exposure to different DMARD: leflunomide, cyclosporin A, methotrexate, mycophenolic acid, FK-506, sulphasalazine and sodium aurothiomala...

W E have previously reponed that treatment with FK 506 and cyclosporine (Cy A) are effective in reversing established acute graft-versus-host disease (GVHD) in an allogeneic rat model. 1 In clinical bone marrow trans-plantation, however, recovery from GVHD has not necessarily been associated with prolongation of survival. 2.3 Therefore. we were interested in comparing the immuno-suppressive age...