We present a family afflicted with a novel autosomal recessive disease characterized by progressive intellectual disability, motor dysfunction and multiple joint contractures. No pathology was found by cranial imaging, electromyography and muscle biopsy, but electron microscopy in leukocytes revealed large vacuoles containing flocculent material. We mapped the disease gene by SNP genome scan an...

The engineering of Saccharomyces cerevisiae strains for lactose utilization has been attempted with the intent of developing high productivity processes for alcoholic fermentation of cheese whey. A recombinant S. cerevisiae flocculent strain that efficiently ferments lactose to ethanol was previously obtained by evolutionary engineering of an original recombinant that displayed poor lactose fer...

Layered double hydroxide (LDH) nanoparticles are emerging as one of the promising nanomaterials for biomedical applications, but their systemic toxicity in vivo has received little attention. In the present study, the effects of inorganic nanoparticle aggregation on their systemic toxicity were examined. Remarkably, aggregation was observed after the mixing of naked LDH nanoparticles with salin...

A model of a galactic disk is presented which extends the homogeneous one zone models by incorporating propagation of material and energy in the disk. For reasonable values of the parameters the homogeneous steady state is unstable to the development of inhomogeneities, leading to the development of spatial and temporal structure. At the linearized level a prediction for the length and time sca...

It is well known that microbes, zooplankton, and fish are important sources of recycled nitrogen in coastal waters, yet marine mammals have largely been ignored or dismissed in this cycle. Using field measurements and population data, we find that marine mammals can enhance primary productivity in their feeding areas by concentrating nitrogen near the surface through the release of flocculent f...

In the Indian Medical Gazette for June 1927, Chopra, Gupta, and David described a new serum test for kala-azar. These workers observed that when certain organic compounds of antimony were brought in contact with the serum from kala-azar patients in a miniature testtube, a thick flocculent precipitate was formed at the junction of the two; whereas with nonkala-azar sera no such precipitation occ...

The use of flocculating yeast strains has been considered as a convenient approach to obtain high cell densities in bioreactors with increasing productivity in continuous operations. In Kluyveromyces marxianus ATTC 10022, the GAP1 gene encodes an isoform of glyceraldehyde-3-phosphate dehydrogenase-p37-that is accumulated in the cell wall and is involved in flocculation. To test the use of p37 a...

A photometric method for quantifying deviations from axisymmetry in optical images of disk galaxies is applied to a sample of 32 face–on and nearly face–on spirals. The method involves comparing the relative fluxes contained within trapezoidal sectors arranged symmetrically about the galaxy center of light, excluding the bulge and/or barred regions. Such a method has several advantages over oth...

In the traditional micromilling (TMM) of Inconel718 alloy, due to influence material plasticity and size effect, relatively large burr will be produced. order hinder forming in micromilling, ultrasonic vibration feed direction is applied workpiece complete cutting. Combined with trajectory simulation cutting experiment, formation mechanism TMM assisted (UVAMM) was studied. The results show that...

This work studied the application of phosphoric acid-gallic acid in vinyl chloride acrylic emulsion and its rust conversion performance. The increase affected stability system, leading to rapid precipitation flocculent precipitation. Rust coating (RCC) showed best synergistic effect when gallic (GA) was 0.2 wt.% (PA) 2 wt.%. XRD FTIR analysis show that components adherent (AR) are α-FeOOH, γ-Fe...