Magnetic Resonance Imaging (MRI) is one of the most powerful noninvasive tools for diagnosing human disease, but its utility is limited because current contrast agents are ineffective when imaging air-tissue interfaces, in regions with low signal-to-noise ratios, or in areas that undergo motion, like the heart and bowel. A technique called dynamic nuclear polarization can be used to hyperpolari...

chiatry 2002;26:197–9. 10. Schoonman GG, Wiendels NJ, Ferrari MD. Gabapentin in migraine prophylaxis: is it effective and well tolerated? Headache 200;42:235. 11. Jeffery SM, Pepe JJ, Popvich LM, Vitagliano G. Gabapentin for hot flashes in prostate cancer. Ann Pharmacother 2002;36:433–6. 12. Chandler A, Williams JE. Gabapentin, an adjuvant treatment for neuropathic pain in a cancer hospital. J ...

A monoclonal T cell-derived suppressor factor specific for the terpolymer poly(LGlu'LAla3LTyr'0) produced by the T-cell hybridoma 258 C4.4, was purified to homogeneity. This was accomplished by fractionation of the culture medium by using a combination of affinity chromatography and reversephase and ion-exchange high-performance liquid chromatography. The purified factor is composed of a single...

Two frog egg lectins [Rana catesbeiana lectin (SBL-C) and Rana japonica lectin] preferentially agglutinate a large variety of human and animal tumor cells but not blood cells, lymphocytes, or fibroblasts. These lectins belong to the superfamily of pyrimidine base-specific RNases. The two lectins bound to a heparin-Sepharose column and were eluted from the column by an increase of NaC! molarity....

Two frog egg lectins [Rana catesbeiana lectin (SBL-C) and Rana japonica lectin] preferentially agglutinate a large variety of human and animal tumor cells but not blood cells, lymphocytes, or fibroblasts. These lectins belong to the superfamily of pyrimidine base-specific RNases. The two lectins bound to a heparin-Sepharose column and were eluted from the column by an increase of NaC! molarity....

Two frog egg lectins [Rana catesbeiana lectin (SBL-C) and Rana japonica lectin] preferentially agglutinate a large variety of human and animal tumor cells but not blood cells, lymphocytes, or fibroblasts. These lectins belong to the superfamily of pyrimidine base-specific RNases. The two lectins bound to a heparin-Sepharose column and were eluted from the column by an increase of NaC! molarity....

Two frog egg lectins [Rana catesbeiana lectin (SBL-C) and Rana japonica lectin] preferentially agglutinate a large variety of human and animal tumor cells but not blood cells, lymphocytes, or fibroblasts. These lectins belong to the superfamily of pyrimidine base-specific RNases. The two lectins bound to a heparin-Sepharose column and were eluted from the column by an increase of NaC! molarity....

We have developed a purification procedure for the isolation of constitutive post-Golgi secretory vesicles from Saccharomyces cerevisiae. Although the post-Golgi stage of the secretion pathway is normally very rapid, we have used a temperature-sensitive secretory mutant, sec 6-4, to greatly expand the population of secretory vesicles. Following invertase as a marker, intact vesicles are enriche...

Natural history museum collections are incomparable storehouses of geological, biological, and genetic resources throughout the world. Some of the materials composing the specimens in these collections are vulnerable to deterioration when stored in fluids. Samples were taken from liquid storage media surrounding mammal specimens in the National Museum of Natural History (NMNH), Smithsonian Inst...

Mutants of Caenorhabditis elegans having about 10% of wild-type activity of the aspartyl protease cathepsin D have been isolated by screening. Mutant homozygotes have normal growth rates and no obvious morphological or developmental abnormalities. The mutant gene (cad-I) has been mapped to the right extremity of linkage group 11. Heterozygous animals ( c a d I / + ) show intermediate enzyme lev...