Whereas for 3-fluorodihydropyridine-substituted carboxylic acids electrophiles such as HCl, iodine, bromine and peracids discriminate the double bond lacking and that bearing fluorine, no such differentiation took place in the case of electrophilic fluorine since the formation of both mono and gem-difluorolactones took place.

A two-step Ir-catalyzed borylation/Pd-catalyzed dehalogenation sequence allows for the net synthesis of fluoroarenes where the boronic ester is ortho to fluorine. Key elements of this approach include the use of a halogen para to the fluorine to block meta Ir-catalyzed borylation and the chemoselective Pd-catalyzed dehalogenation by KF activated polymethylhydrosiloxane (PMHS).

One-electron oxidation converts the ferrocene-substituted borane into a Lewis superacid, as reported by Frank Breher, Jan Paradies, and co-workers in their Communication (e202216959). The superacid activates almost inert carbon–fluorine sulfur–fluorine bonds for reductions, alkylations, arylations to form new chemical bonds.

We consider the model with discrete innovations introduced in [1] and studied in [2–9]. In this model the state of the economy is determined by a set of operating technologies, a collection of funds corresponding to these technologies, and a set of known, but as yet not implemented technologies. To introduce a new technology, expenditures of the already utilized types of funds are required. As ...

There have been significant advances in the calculation and interpretation of indirect nuclear spin-spin coupling (J) tensors during the past few years; however, much work remains to be done, especially for molecules containing heavy atoms where relativistic effects may play an important role. Many J tensors cannot be explained based solely on a nonrelativistic Fermi-contact mechanism. In the p...

treatment of tuberculosis (tb) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. in the present study, fluorinated analogs of some of the most important anti-tb agents such as p-aminosalicylic acid (pas), thiacetazone and pyrazinamide were synthesized and tested against tb. the fluorinated analog of thiace...

Abstract Fluorosis is the most widespread and serious endemic disease in abandoned Yellow River flooding delta of East China. One important causes fluorosis drinking high-fluorine groundwater. In this study, 313 groundwater samples were collected central part to address chemistry high-fluoride groundwater, 33 core from one borehole 150 m depth analyse vertical distribution characteristics total...