Brachial artery flow-mediated dilation (FMD) is a strong predictor of future cardiovascular disease and is believed to represent a "barometer" of systemic endothelial health. Although a recent study [Padilla et al. Exp Biol Med (Maywood) 235: 1287-1291, 2010] in pigs confirmed a strong correlation between brachial and femoral artery endothelial function, it is unclear to what extent brachial ar...

OBJECTIVE/BACKGROUND Biomarker(s) for prediction of the future progression rate of abdominal aortic aneurysms (AAA) may be useful to stratify the management of individual patients. AAAs are associated with features of systemic inflammation and endothelial dysfunction. Flow mediated dilatation (FMD) of the brachial artery is a recognised non-invasive measurement for endothelial function. We hypo...

Foot-and-mouth disease (FMD) epidemics recur in Israel almost every year. Wild even-toed ungulates are seldom affected during these epidemics. The seroprevalence of FMD in wild ungulates during 2000 and 2005-2013 was estimated using anti-non-structural proteins ELISA. Overall, 209 samples were tested, comprising sera of 120 wild boar (Sus scrofa lybicus), 64 mountain gazelles (Gazella gazella g...

BACKGROUND Flow-mediated dilatation (FMD) of the brachial artery represents systemic endothelial function, so the relationship between FMD and blood pressure (BP) profile, in relation to the effects of cigarette smoking, was investigated in young healthy subjects. METHODS AND RESULTS The 62 healthy subjects (14 females, 48 males; mean 29.7+/-5.5 years old), were divided into a smoking group (...

A retrospective, single-center review was performed from January 2013 to June 2018. Sixty-one patients (23 children and 38 adults; aged 3-30 years) with renal artery fibromuscular dysplasia (FMD) had undergone balloon angioplasty for severe hypertension, 2 requiring bail-out stenting. Blood pressure improved in 19 (8 normalized, 11 decreased) of 21 branch FMD during follow-up. The incidence sig...

PURPOSE To examine the effects of exercise intensity on acute changes in endothelial function in lean and obese adults. METHODS Sixteen lean (BMI <25, age 23 ± 3 yr) and 10 obese (BMI >30, age 26 ± 6 yr) physically inactive adults were studied during 3 randomized admissions [control (C, no exercise), moderate-intensity exercise (M, @ lactate threshold (LT)) and high-intensity exercise (H, mid...

BACKGROUND Impaired vascular function occurs early in atherogenesis. Brachial flow mediated dilatation (FMD) is a non-invasive measure of vascular function and may be an important marker of preclinical atherosclerosis. Data on the association between FMD and carotid plaque in multi-ethnic populations are limited. The objective of this study was to determine whether endothelial dysfunction is in...

Aging is associated with a decline in vascular endothelial function, manifesting in part as impaired flow-mediated arterial dilation (FMD), but the underlying mechanisms are uncertain. Impaired FMD may be mediated in part by a decrease in synthesis of nitric oxide by endothelial nitric oxide synthase, and in clinical populations this has been attributed to competitive inhibition of l-arginine b...

The objectives of our study were to examine 1) the proportion of responders and nonresponders to exercise training in terms of vascular function; 2) a priori factors related to exercise training-induced changes in conduit artery function, and 3) the contribution of traditional cardiovascular risk factors to exercise-induced changes in artery function. We pooled data from our laboratories involv...

OBJECTIVES We studied whether assessment of endothelium-dependent vasomotion (EDV) with brachial artery ultrasound (BAUS) imaging predicts the presence or absence of coronary artery disease (CAD) as defined by exercise myocardial perfusion imaging (ExMPI). BACKGROUND Abnormalities in EDV can be detected in arteries before the development of overt atherosclerosis, and its presence may predict po...