Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only parti...

with rapid changes in the business environment, organizations are increasingly looking at human resources as a unique asset that can provide sustained competitive advantage. as much as, people are viewed among the most important resources to firms, hr strategy would be central to achieve competitive advantages .firms should view hr strategy as an important tool for integrating competencies insi...

Background: The key challenge is how to encourage and retain health professionals in their work location. There is a list of policy options for this purpose but applying an appropriate and effective set of strategies requires a country level research. Our study aimed to identify retention strategies for neurosurgeons and examine both the importance and feasibility of the identified strategies u...

As countries around the world struggle to provide oncology care and treatment to their populations, nurses, as the largest healthcare workforce, are faced with the challenge of obtaining, maintaining, and developing specialized oncology nursing knowledge and expertise. Strategies that can be deployed at a local level to support nurses with integrating new knowledge into practice are important i...

De Vrijer has presented a proof of the finite developments theorem which, in addition to showing that all developments are finite, gives an effective reduction strategy computing longest developments as well as a simple formula computing their length. We show that by applying a rather simple and intuitive principle of duality to de Vrijer’s approach one arrives at a proof that some developments...

A hybrid approach that combines the (1+1)-ES and threshold selection methods is developed. The framework of the new experimentalism is used to perform a detailed statistical analysis of the effects that are caused by this hybridization. Experimental results on the sphere function indicate that hybridization worsens the performance of the evolution strategy, because evolution strategies are well...

Throughout their lives, women provide for their own and their children's and grandchildren's needs and thus must minimize their risk of incurring physical harm. Alliances with individuals who will assist them in attaining these goals increase their probability of survival and reproductive success. High status in the community enhances access to physical resources and valuable allies. Kin, a mat...

The main goal of this commentary is to provide a brief checklist proposal for a possible second meeting with the patient, particularly when prescriptions and therapeutic indications provided in the first meeting were not totally or partially followed. In the second meeting please ask yourself the following question: “Where was my behavior lacking in the first meeting? In the “relationship,” “co...