Introduction: Tuberculosis (TB), caused by Mycobacterium Tuberculosis (Mtb), with more than nine million new cases and almost two million deaths in each year is a worldwide important public health problem. Generally, human immune responses prevent Mtb spread, and the infection remains in a latent state. Both, innate and adaptive immune responses are involved against TB. However, the role of the...

In protein fold recognition, a probe amino acid sequence is compared to a library of representative folds of known structure to identify a structural homolog. In cases where the probe and its homolog have clear sequence similarity, traditional residue substitution matrices have been used to predict the structural similarity. In cases where the probe is sequentially distant from its homolog, we ...

Abstract Recurrent glioblastoma (GBM) is an aggressive disease with poor survival and limited treatment options. SL-701 a novel immunotherapy comprised of synthetic peptides designed to elicit anti-tumor immune response against GBM antigens IL-13Rα2, ephrinA2, survivin. Here we describe 18-color flow cytometry analysis from stage 2 Ph2 clinical trial SL-701+poly-ICLC+bevacizumab (NCT02078648), ...

intestinal parasitosis has been a major public health problem in iran. it is necessary to evaluate an up-date data in this regard to be used by local authorities. serum ige determinations and coproparasitological analyses were conducted on 1200 individuals in city of ghaemshahr, mazandaran province, northern iran. a total of 1200 subjects were taken stool samples for three days consecutively. t...

Neural network (NN)-based modeling often involves trying multiple networks with diierent architectures and training parameters in order to achieve acceptable model accuracy. Typically, one of the trained NNs is chosen as best, while the rest are discarded. Hashem and Schmeiser 25] proposed using optimal linear combinations of a number of trained neural networks instead of using a single best ne...

The activities of ampicillin, ampicillin-sulbactam, amoxicillin, amoxicillin-clavulanic acid, ticarcillin, ticarcillin-clavulanic acid, piperacillin, piperacillin-tazobactam, aztreonam, and aztreonam-clavulanic against Stenotrophomonas maltophilia strains for which the MICs of penicillins and commercially available b-lactam– b-lactamase inhibitor combinations were higher than the breakpoints us...

The fold of human aquaporin 1 is determined from cryo-electron microscopic data at 4.5 A resolution. The monomeric structure consists of two transmembrane triple helices arranged around a pseudo-2-fold axis connected by a long flexible extracellular loop. Each triplet contains between its second and third helix a functional loop containing the highly conserved fingerprint NPA motif. These funct...

DNA barcoding is expected to be one of the most promising tools in biological taxonomy. However, there have been no agreements on which core barcode should be used in plants, especially in species-rich genera with wide geographical distributions. To evaluate their discriminatory power in large genera, four of the most widely used DNA barcodes, including three plastid regions (matK, rbcL, trnH-p...