نتایج جستجو برای: follicle stimulating hormone receptor

تعداد نتایج: 741430  

Journal: :Pharmacogenomics 2014
Belen Lledo Jose A Ortiz Joaquin Llacer Rafael Bernabeu

Effective controlled ovarian stimulation (COS) is crucial for IVF outcome. Ovarian response to follicle-stimulating hormone, however, varies widely among women undergoing ovarian stimulation. Advance identification of patients who will elicit a poor or high response to standard treatment would be of great clinical benefit for such patients. Application of pharmacogenetics to ovarian response ma...

Journal: :Recent progress in hormone research 2002
Leslie L Heckert Michael D Griswold

Results from experiments using mouse models suggest that the role of follicle-stimulating hormone (FSH) in spermatogenesis is the regulation of Sertoli cell proliferation and, ultimately, the size and spermatogenic capacity of the testis. The regulation of the expression of the FSH receptor (FSHR) gene is very cell specific and plays an initial role in the ultimate response of the Sertoli cells...

2014
Xuliang Jiang David Fischer Xiaoyan Chen Sean D. McKenna Heli Liu Venkataraman Sriraman Henry N. Yu Andreas Goutopoulos Steve Arkinstall Xiaolin He

Follicle-stimulating hormone receptor (FSHR), a G-protein coupled receptor, is an important drug target in the development of novel therapeutics for reproductive indications. The FSHR extracellular domains were observed in the crystal structure as a trimer, which enabled us to propose a novel model for the receptor activation mechanism. The model predicts that FSHR binds Asnα(52)-deglycosylated...

2014
Marco Antonio Botelho Dinalva Brito Queiroz Gisele Barros Stela Guerreiro Pierre Fechine Sonia Umbelino Arão Lyra Boniek Borges Allan Freitas Danilo Caldas de Queiroz Ronaldo Ruela Jackson Guedes Almeida Lucindo Quintans

OBJECTIVE To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms. METHODS A total of 66 postmenopausal Brazilian women with climacteric symptoms of natural menopause received transdermal nanostructured formulations of progesterone and estrogens in the forearm ...

Journal: :Human reproduction 1996
S Mancuso A Caruso A Lanzone

ARTICLES Endocrinology Acarbose reduces elevated testosterone serum concentrations in hyperinsulinaemic premenopausal women: a pilot study Preconceptional and gestations! evaluation of insulin secretion in patients with polycystic ovary syndrome Nuclear maturity and oocyte morphology after stimulation with highly purified follicle stimulating hormone compared to human menopause! gonadotrophin V...

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