Thyroid is a H-shaped gland localised in front of trachea at the base of the neck, whose main functions are the synthesis, the storage and the secretion of thyroid hormones under the control of the hypothalamic–pituitary axis. Thyroid is comprised of spherical follicles filled with colloid that are lined by cuboidal/flat epithelial cells denoted follicular cells (or thyrocytes). The other hormo...

OBJECTIVE Due several overlapping histomorphological features and pitfalls in thyroid pathology, there is need to establish a panel of immunomarkers that would aid in proper diagnosis. This study was carried out to investigate the ability of HBME-1, CK19, and S100 in differentiating between hyperplastic, benign and malignant thyroid lesions. MATERIALS AND METHODS Immunohistochemical analysis ...

Introduction Follicular thyroid cancer, similar to follicular adenoma, usually takes the form of a round, encapsulated tumour. Cytological examination does not allow a firm diagnosis of follicular thyroid cancer to be made. Follicular thyroid cancer can be diagnosed by histopathological examination only after demonstrating the infiltration of the capsule by the tumour and/or vessel invasion. Th...

BACKGROUND Collision tumors of the thyroid gland are a rare entity. We present a case of a follicular variant of papillary carcinoma and squamous carcinoma in the thyroid. To the best of our knowledge, this is the first documentation of a collision tumor with a papillary carcinoma and a squamous carcinoma within the thyroid gland. The clinicopathological features and immunohistochemical profile...

Primary spindle cell neoplasms of the thyroid gland are quite rare. They encompass a heterogeneous group of benign and malignant lesions of mesenchymal and epithelial origin. We herein describe two unusual follicular thyroid adenomas dominated by spindle cells with occasional areas of colloid-forming follicular differentiation. The tumors affected a 77-year woman and a 70-year old man; both had...

Background: Papillary thyroid carcinoma is the most common thyroid cancer (85%). Follicular thyroid carcinoma is the second most common type of thyroid cancer, accounting for up to 10% of all thyroid cancers. Medullary thyroid carcinoma accounts for only 5–8% of thyroid cancers. Concurrent medullary, follicular, and papillary carcinomas of the thyroid Received: April 22, 2014 Accepted after rev...

Malignant tumors arising from follicular cysts are rare. Herein, we report of a 62-year-old Japanese woman with a slowly growing tumor, 22 × 20 mm in size, located on her nose for 2 years. Histopathological examination of the surgically excised tumor showed that the tumor cells were basaloid and formed peripheral palisading patterns. The tumor contained a cystic structure in its center, and the...

Cytokeratin 19 (CK19) is one of the most frequently studied immunohistochemical markers in thyroid pathology. The results of several studies suggest that CK19 may be useful in the diagnosis of papillary carcinoma, where it has been shown to have strong diffuse cytoplasmic reactivity. However, the published results vary, and the utility of CK19 in the diagnosis of thyroid lesions is controversia...

background: fine needle aspiration (fna) has led to a decrease in unnecessary surgeries for thyroid nodules. this study was designed to compare diagnostic value of fna and frozen section methods in the follicular lesions. methods: this is a cross-sectional study based on the medical records of 42 patients who were referred to surgery clinic of rasool-e-akram hospital in tehran with complaint of...

BACKGROUND There are inter-observer disagreements between papillary thyroid carcinoma (PTC) with other follicular lesions of thyroid in aspect of diagnosis. CD56 is present on follicular epithelial cells of the normal thyroid. We evaluated the diagnostic value of CD56 expression in PTC, follicular thyroid lesions, and follicular thyroid neoplasms. MATERIALS AND METHODS Seventy-three cases dia...