This case represents occult follicular variant of papillary thyroid carcinoma (FVPTC) with large metastasis to the sacrum. The patient, a 42-year-old female, presented after hemithyroidectomy for benign follicular adenoma with lower back pain associated with fever and sweating. A lytic lesion of the left sacral bone was found on the CT with biopsy showing metastatic carcinoma with morphology an...

According to the literature thyroid nodules are quite rare in the first two decades of life. However, there are some exceptions, relating to areas with an iodine deficiency or affected by radioactive fallout, where the risk of nodules and carcinomas is increased. Therefore, it is a great challenge for the physician to distinguish between benign and malignant lesions preoperatively, and not only...

Thyroid carcinoma is the most common malignant endocrine neoplasia. Differentiated thyroid carcinomas (DTCs) represent more than 90% of all thyroid carcinomas and comprise the papillary and follicular thyroid carcinoma subtypes. Anaplastic thyroid carcinomas correspond to less than 1% of all thyroid tumors and can arise de novo or by dedifferentiation of a differentiated tumor. The etiology of ...

background: carcinomas of the thyroid follicular epithelium are the most common cancers of the endocrine system. in the diagnosis of thyroid nodules and tumors, the gold standard is histological evaluation. in cases which have morphological overlap,immunohistochemistry is needed for differential diagnosis. the purpose of this study is to investigate the expressions of cd56,hbme?1, cytokeratin 1...

Papillary carcinoma and follicular carcinoma are types of differentiated thyroid carcinomas, develop from the same thyroid follicular epithelial cells and show distinct biological behavior. Although several studies have demonstrated differences in the biological characteristics of these carcinomas, little is known about the genetic backgrounds that underlie these differences. The clarification ...

Thyroid cancer is common type of malignant tumor in humans, and the autophagy status of such tumors may vary according to subtype. This study aimed to investigate the expression and implications of the major autophagy-related molecules light chain (LC) 3A, LC3B, p62, and BNIP-3 in human thyroid carcinoma. Tissue microarrays were constructed from 555 thyroid cancers (papillary thyroid carcinoma ...

Thyroid nodules are uncommon in children (1.5%). However, the incidence of thyroid carcinoma in childhood thyroid nodules (26.4%) is 3-4 folds higher than in adults. Autonomously functioning thyroid nodules (AFTN) or hot nodules account for less than 3% of hyperthyroidism in children and carry a small risk of malignancy (2-5%). The majority of malignant hot nodules are papillary thyroid carcino...

This case report is the fourth case documented of a patient with synchronous Follicular, Papillary, and Medullary Thyroid Carcinoma. There have been several case series in the last two decades that include either concurrent papillary-medullary or follicular-medullary thyroid carcinoma, but only three cases documented for all three of these types of thyroid carcinomas occurring in the same patie...

Thyroid stimulating hormone (TSH)-associated follicular hypertrophy and hyperplasia as a mechanism of thyroid carcinogenesis in mice and rats G. A mechanistic relationship between thyroid follicular cell tumours and hepatocellular neoplasms in rodents Human renal-cell carcinoma—epidemiological and mechanistic aspects A. Mellemgaard Human renal carcinoma—pathogenesis and biology J.B. Beckwith a ...

In a 59-year-old patient, thyroid follicular cancer was diagnosed in two right-sided toxic thyroid nodules, which had presented clinically as unilateral thyroid autonomy. In addition, the patient had histologically proven lung metastases of thyroid cancer; however, these failed to exhibit iodine uptake and were resistant to radioiodine treatment. The functional activity of the thyroid nodules p...