The prediction of diffuse herbicide losses to surface waters using process-based models is data and time demanding. There is a need for simpler and more efficient catchment screening tools. We developed and tested a new proxy for screening catchments for their vulnerability to diffuse herbicide losses relying on widely available river flow data only. The proxy combines the fast flow index (FFI)...

With the aim of more emphasis on pragmatics and its inclusion in EFL classrooms, this study attempted to investigate the effectiveness of obtrusive and unobtrusive focus on form instructions on learners’ pragmatic performance of criticizing in English. 54 Iranian learners, all at intermediate level, participated in this study, and they were divided into three groups: 19 participants receiving o...

Inherited human prion diseases, such as fatal familial insomnia (FFI) and familial Creutzfeldt-Jakob disease (fCJD), are associated with autosomal dominant mutations in the human prion protein gene PRNP and accumulation of PrPSc, an abnormal isomer of the normal host protein PrPC, in the brain of affected individuals. PrPSc is the principal component of the transmissible neurotoxic prion agent....

INTRODUCTION The definitive diagnosis of genetic prion diseases (gPrD) requires pathological confirmation. To date, diagnosis has relied upon the finding of the biomarkers 14-3-3 protein and total tau (t-tau) protein in the cerebrospinal fluid (CSF), but many researchers have reported that these markers are not sufficiently elevated in gPrD, especially in Gerstmann-Sträussler-Scheinker syndrome...

BACKGROUND Sporadic fatal insomnia (sFI) and fatal familial insomnia (FFI) are rare human prion diseases. CASE PRESENTATION We report a case of a 33-year-old female who died of a prion disease for whom the diagnosis of sFI or FFI was not considered clinically. Following death of this patient, an interview with a close family member indicated the patient's illness included a major change in he...

This paper presents an experiment concerning the relative effectiveness of computer assisted comprehension practice and production practice in the acquisition of a second language. Two computer programs were developed: (a) an input-focused program providing students with explicit grammatical instruction and comprehension exercises and (b) an output-focused program providing the same grammatical...

A crucial tenet of the prion hypothesis is that misfolding of the prion protein (PrP) induced by mutations associated with familial prion disease is, in an otherwise normal mammalian brain, sufficient to generate the infectious agent. Yet this has never been demonstrated. We engineered knockin mice to express a PrP mutation associated with a distinct human prion disease, fatal familial insomnia...

Traditional conceptions of interpersonal flexibility emphasize two critical components: (a) a wide range of interpersonal responses and (b) situational appropriateness. Most current measures are based on standard trait ratings, which cannot address situational adjustment. In place of trait ratings, we suggest the use of capability ratings, that is, self-reports of the ease of performing social ...

Students have trouble using and interpreting topographic maps. Experienced map-users identify patterns of contour lines representing topographic structures and visualize that information in 3D. Novices struggle with both recognizing 2D patterns and visualizing 3D structures from contour lines. In this study, the Pattern Identification group received instruction focused on identifying contour pa...