M ultiple sclerosis (MS) is a damaging CNS disease. Because the CNS has inherent properties that prevent the damage from manifesting readily (e.g., redundancy, plasticity, repair), often irreversible damage is not appreciated until very late. Pathologically it is apparent that permanent and irreversible damage occurs very early in MS plaque formation. Treatment of the disease course can therefo...

Checkpoint proteins protect the genomic integrity of a cell, repeatedly impaired by DNA damage and normal cellular processes, such as replication. Checkpoint proteins hRad9, hRad1, and hHus1 form a heterotrimeric complex that is thought to act as a genomic surveyor of DNA damage. We show here that, when DNA double-strand breaks (DSBs) are specifically generated in a subnuclear area, hRad9 is ra...

DNA damage is one of the most common insults that challenge all cells. To cope, an elaborate molecular and cellular response has evolved to sense, respond to and correct the damage. This allows the maintenance of DNA fidelity essential for normal cell viability and the prevention of genomic instability that can lead to tumor formation. In the context of oocytes, the impact of DNA damage is not ...

Abstract – In this paper, the effect of applied electric field on the damage due to partial discharges activity into the surroundings dielectrics of a narrow channel encapsulated within the volume of a dielectric material is evaluated using a kinetic model based on Particle in Cell - Monte Carlo Collision (PIC-MCC) model. After application of an electric field across a dielectric material which...

Checkpoint proteins protect the genomic integrity of a cell, repeatedly impaired by DNA damage and normal cellular processes, such as replication. Checkpoint proteins hRad9, hRad1, and hHus1 form a heterotrimeric complex that is thought to act as a genomic surveyor of DNA damage. We show here that, when DNA double-strand breaks (DSBs) are specifically generated in a subnuclear area, hRad9 is ra...

Background: Treatment of ionizing radiation combined with chemical agents can enhance the inactivation of cells. The aim of this study was to determine the parameters involved in the inhibition of cell recovery. Materials and Methods: A mathematical model describing the process of recovery as a decrease in the effective radiation dose was used. The model includes two parameters, recovery consta...

in this paper, a crack localization method for euler-bernoulli beams via an efficient static data based indicator is proposed. the crack in beams is simulated here using a triangular variation in the stiffness. static responses of a beam are obtained by the finite element modeling. in order to reduce the computational cost of damage detection method, the beam deflection is fitted through a poly...

results of damage prediction in buildings can be used as a useful tool for managing and decreasing seismic risk of earthquakes. in this study, damage spectrum and c4.5 decision tree algorithm were utilized for damage prediction in steel buildings during earthquakes. in order to prepare the damage spectrum, steel buildings were modeled as a single-degree-of-freedom (sdof) system and time-history...