in recent decades, as the result of industrial life, consuming fried and fast foods have increased significantly. excessive use of fat, especially saturated fats and trans fatty acids is one of the important factors that increases heart diseases, weight gain, and cancers. therefore, using effective methods for decreasing fat absorption not only retains desirable features but also seems essentia...

prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. the objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. metoclopramide hydrochloride is a potent antiemetic an...

Abstract Bacterial conjunctivitis characterized as pink eye referred as an inflammation of an eye caused by the enlargement of blood vessels present in conjunctiva, resulting in a red or bloodshot appearance of the eyes. Topical ocular delivery is found to be useful in treating conjunctivitis, but to maintain an effective drug concentration at a site of action in order to achieve desired pha...

angelica essential oil (ao), a major pharmacologically active component of angelica sinensis (oliv.) diels, possesses hemogenesis, analgesic activities and sedative effect. the application of ao in pharmaceutical systems had been limited because of its low oxidative stability. the ao-loaded gelatin-chitosan microcapsules with prevention from oxidation were developed and optimized using response...

an oral sustained-release floating tablet formulation of metformin hcl was designed and developed. effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and hpmc-peo polymer combination, respectively. tablet composition was optimized by response surface methodology (rsm). seventeen (17) trial formulations were analyzed according to box-behnken desi...

the aim of this work was to develop and evaluate a minoxidil foamable emu oil emulsion with the purpose of improving minoxidil permeation into the skin, increasing hair growth , reducing skin irritation, and increasing consumer compliance. minoxidil was dissolved in a solvent system comprising ethanol: glycerin: lactic acid: water (10:20:5:65). the foamable emulsion was prepared by mixing the o...

background: anti-microbial agents have been used as a chemotherapeutic agent to improve oral health. this in vitro study was carried out to determine antimicrobial efficacy of different toothpastes and mouthrinses against the oral pathogens.     methods: a total of five toothpastes and five mouthrinses were tested for their antimicrobial activity against three oral pathogens namely, streptococc...

the objective of the present study was to optimize awettable powder formulation for twoiranianbtstrains (yd5 and kh4) in order to enhance efficiency and durability as biological agent against lepidopteran and coleopteran pests.mass production of the mentioned strains was done in a batch fermentor based on the peviouselyoptimized economical medium and fermentation conditions, and the final conce...