The aims of this study were to develop and characterize paclitaxel nanoparticles, to identify and control critical sources of variability in the process, and to understand the impact of formulation and process parameters on the critical quality attributes (CQAs) using a quality-by-design (QbD) approach. For this, a risk assessment study was performed with various formulation and process paramet...

Abstract In this paper the novel hybrid manipulator, named as CaHyMan (Cassino Hybrid Manipulator), is analyzed in term of stiffness characteristics. A formulation is presented to deduce the stiffness matrix as a function of the most important stiffness parameters of the mechanical design. The specific design of CaHyMan, which has been designed and built at the Laboratory of Robotics in Cassino...

This article aims to develop a probability-based model involving the use of direct likelihood formulation and generalised linear modelling (GLM) approaches useful in estimating important disease parameters from longitudinal or repeated measurement data. The current application is based on infection with respiratory syncytial virus. The force of infection and the recovery rate or per capita loss...

A rigorous formulation of the parametric yield for very large scale integration (VLSI) designs including the mismatch effect is proposed. The theory has been carried out starting from a general statistical model relating random variations of device parameters to the stochastic behavior of process parameters. The model predicts a dependence of correlation, between devices fabricated in the same ...