Many polymers exhibit much steeper temperature dependence of their structural relaxation time (higher fragility) than liquids of small molecules, and the mechanism of this unusually high fragility in polymers remains a puzzle. To reveal additional hints for understanding the underlying mechanism, we analyzed correlation of many properties of polymers to their fragility on example of model polym...

OBJECTIVE The prevalence of subclinical contributors to low bone mineral density (BMD) and/or fragility fracture is debated. We evaluated the prevalence of subclinical contributors to low BMD and/or fragility fracture in the presence of normal 25-hydroxyvitamin D (25OHVitD) levels. DESIGN Prospective observational study. METHODS Among 1095 consecutive outpatients evaluated for low BMD and/o...

UNLABELLED In this study, we demonstrate a high prevalence of secondary factors in patients with a recent fracture independently of bone mineral density (BMD). Our results suggest that patients with a recent fracture should be screened for secondary factors for bone fragility regardless of BMD values. INTRODUCTION Secondary factors for bone fragility are common in patients with osteoporosis w...

INTRODUCTION F OLLOWING Haden’s1#{176}demonstration of the close correlation between spherocytosis and the fragility of erythrocytes to hypotonic saline, Dameshek and Miller5 postulated that spherocytosis was a preliminary stage in the destruction of the red cell; i.e. partial hemolysis. They were able to show experimentally that the degree of spherocytosis was related to the concentration of h...

A precise and highly reproducible method for analyzing the osmotic fragility of erythrocytes with a minute amount of blood (less than 10 mul) is described. The osmotic fragility curves are recorded with a coil planet centrifuge with accessories and a scanning photodensitometer. The recorded curves are transcribed by a DuPont Curve Resolver and their components are analyzed. Normal fragility cur...

The concept of fragility provides a possibility to rank different supercooled liquids on the basis of the temperature dependence of dynamic and/or thermodynamic quantities. We recall here the definitions of kinetic and thermodynamic fragility proposed in the last years and discuss their interrelations. At the same time we analyze some recently introduced models for the statistical properties of...

The two major intermediate filament proteins in glandular epithelia are keratin polypeptides 8 and 18 (K8/18). To evaluate the function and potential disease association of K18, we examined the effects of mutating a highly conserved arginine (arg89) of K18. Expression of K18 arg89-->his/cys and its normal K8 partner in cultured cells resulted in punctate staining as compared with the typical fi...

The concept of 'fragility' constitutes a central point of the glass transition science serving as the 'universal' metric linking previtreous dynamics of qualitatively distinct systems. Finding the fundamental meaning of fragility is the 'condicio sine qua' for reaching the long expected conceptual breakthrough in this domain. This report shows that fragility is determined by the ratio between t...

Lenders condition future loans on some index of past performance. Typically, banks condition future loans on repayments of earlier obligations while international organizations condition future loans on the implementation of some policy conditions. We build an agency model that accounts for these tendencies to offer an explanation for why both types of conditionality clause may coexist. The opt...

fragility curves represent the probabilities that structural damages, under various levels of seismic excitation, will exceed the specified damage states by means of earthquake intensity damage relations. conceptual aspects related to seismic vulnerability, damage and risk evaluation are discussed first, together with a short review of the most widely used possibilities for the seismic evaluati...