Background. The predictive value of frailty assessment is still debated. We analyzed the predictive value of frailty of independent living elderly. The outcomes variables were visits to the general practitioner, hospital admission, and occurrence of new health problems. Methods. A one-year follow-up study was executed among 215 community-living old Romanians. General practitioners reported the ...

BACKGROUND Long-term predictors of geriatric syndrome of frailty are unclear. Several obesity-related conditions are associated with frailty. This study examines the predictive role of midlife overweight and obesity on development of frailty more than 22 years of follow-up. METHODS Data are from 1,119 men and women aged 30 or older without frailty at baseline participating in a population-bas...

OBJECTIVES to evaluate the association between dehydroepiandosterone (DHEA) and physical frailty in older adults. DESIGN cross-sectional analysis of baseline information from three separate studies in healthy older men, women and residents of assisted living. SETTING academic health centre in greater Hartford, CT, USA. PARTICIPANTS eight hundred and ninety-eight adults residing in the com...

Survival analyses are greatly used in medical research especially frailty models which are mostly used to account for heterogeneity in time-to-event. Over the years treatment of cancer has progressed with some patients being cured from different type of cancer. Survival analysis is more focused on subjects that are less at risk of recurrences, metastasis or death after the first treatment as th...

BACKGROUND Older adults use more health-care services per capita than younger age groups and the older adult population varies greatly in its needs. Evidence suggests that there is a critical distinction between relative frailty and fitness in older adults. Here, we review how frailty is described in the pre-hospital literature and in the broader emergency medicine literature. METHODS PubMed ...

BACKGROUND Frailty is a common risk factor for morbidity and mortality in elderly persons. Recent evidence links frailty to activation of coagulation and inflammatory pathways. We aimed to determine whether frailty in community-dwelling older adults is a risk factor for venous thromboembolism (VTE). METHODS We conducted a prospective cohort study in four U.S. communities involving 4859 partic...

OBJECTIVES This study aimed to explore the concordance between definitions of sarcopenia and frailty in a clinically relevant population of geriatric outpatients. DESIGN Data were retrieved from a cross-sectional study. SETTING The study was performed in a geriatric outpatient clinic of a middle-sized teaching hospital. PARTICIPANTS The study included 299 geriatric outpatients (mean age 8...

Introducing a random effect into the Cox model is a useful tool forbuilding hierarchical families of univariate semiparametric regressionsurvival models. Hougaard [1984] used the Laplace transform to buildfrailty models with explicitly defined survival functions and random ef-fects. The family derived from stable distributions was then extended[Aalen, 1992] to frailty va...

In the standard frailty model the hazard function i s taken to be proportional to an unobserved random effect, specific to the individual. These frailties are the n taken to be independent realisations from a proba bility distribution of assumed form, and they are integrat ed out to form the likelihood function for the obse rved failure time data. In real applications the assumed istrib ution f...

The impact of antiretroviral therapy (ART) on frailty among human immunodeficiency virus (HIV)-infected adults has not been well described. HIV-infected participants aged ≥40 years with initial ART receipt through a randomized, controlled AIDS Clinical Trials Group trial completed a frailty assessment. Ordinal logistic regression models examined factors associated with frailty. Of 1016 particip...