Perfluorocarbon (PFC) double emulsions loaded with a water-soluble, therapeutic agent can be triggered by ultrasound in a process known as acoustic droplet vaporization. Elucidating the stability and biodistribution of these sonosensitive vehicles and encapsulated agents is critical in developing targeted drug delivery strategies using ultrasound. [(18) F]fluorodeoxyglucose (FDG) was encapsulat...

Two species of Australian Cyrtoscydmini were placed in the subgenus Magellanoconnus Franz of Sciacharis Broun: S. carinifrons (Franz) and S. kangarouana (Franz) (both originally described in Neuraphoconnus, a junior synonym of Magellanoconnus Franz). Examination of type specimens revealed that these species names, published in the same paper, are synonymous and S. carinifrons is here selected a...

Amphiphilic copolymers containing polydimethylsiloxane (PDMS) and polyethylene glycol methyl ether (MPEG) were obtained via an azide-alkyne cycloaddition reaction between alkyne-functionalized copolymer of MPEG methacrylate azide-functionalized PDMS. “Click” reactions carried out with efficiency 33–47% increasing grafting degrees. The grafted able to carry the micellization encapsulation active...

Abstract: Aim: The present work intends to formulate and evaluate film forming solution of diphenhydramine. Materials Methods: Film solutions (FFS) for transdermal delivery Diphenhydramine HCl were prepared using different polymers (hydroxypropyl cellulose, Eudragit L 100, polyvinylpyrollidone K30 K90), PEG 400 as plasticizer ethyl alcohol solvent. Results: found display an acceptable drying ti...

The production of ergosterol lipid involves the activity different enzymes and is a crucial event for Leishmania membrane homeostasis. Such can be blocked by azoles allylamines drugs, such as antifungal butenafine chloride. This drug was active on parasites that cause cutaneous visceral leishmaniasis. Based leishmanicidal chloride considering absence reports about therapeutic potential this in ...

Abstract This research aimed to prepare and characterize a new type of polymeric cross-linked topical hydrogel patches for the treatment wound infections. The free radical polymerization method was used by utilizing natural polymers, i.e., agarose gelatin. These polymers were chemically with monomer (acrylic acid) using ammonium persulfate as an initiator via cross-linker N , methylene bisacryl...

Iodine preparations for external use are recommended for treating pressure ulcers with manifestations of infection and necrosis. These ulcers abundantly produce wound exudates, which could be absorbed by water-soluble base. In this study we aimed to improve the previously reported methodologies for water absorption and new methodologies were developed in Franz diffusion cell with 100kDa molecul...

Sciacharis s. str. is redefined based on the morphology of its type species, S. fulva Broun, and compared with sympatric genera Chathamaenus Franz (endemic to New Zealand) and Maorinus Franz (known from New Zealand and Australia). As a result, Chathamaenus is placed as a junior synonym of Sciacharis s. str., and Maorinus, originally described as a subgenus of Euconnus Thomson (under a preoccupi...

This paper describes a comparative study on the performances of ethosomes and solid lipid nanoparticle as delivery systems for acyclovir. Ethosomes were spontaneously produced by dissolution of phosphatidylcholine and acyclovir in ethanol followed by addition of an aqueous buffer while solid lipid nanoparticle were produced by homogenization and ultrasonication. Both colloidal systems were morp...

The objective of this study was to evaluate pharmacodynamical properties of transdermal therapeutic systems (TTS) containing captopril together with synthetic and pH independent polymers, Eudragit RL 100 and RS 100. Optimum formulation was chosen according to the results of our previous study regarding in vitro dissolution and ex vivo diffusion rate studies through excised human skin by using F...