Female hormones are thought to be of importance in the aetiology of migraine, which is more common in women than in men. Little attention has been paid to androgens. This study investigates the associations between migraine and serum levels of androgens in postmenopausal women not taking oestrogens. A case-control study was carried out among women participating in a mammography screening progra...

OBJECTIVE To describe the sources, production rates, circulating concentrations, and regulatory mechanisms of the major androgen precursors and androgens in women. DESIGN Review of the major published literature. RESULT(S) Quantitatively, women secrete greater amounts of androgen than of estrogen. The major circulating steroids generally classified as androgens include dehydroepiandrosteron...

BACKGROUND Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex steroid status. Some studies also investigated the association of testosterone level with diabetes risk in men, but reported controversial findings. To clarify this issue, we conducted a systematic review and meta-analysis. METHODS PubMed, EMBASE and Web of Science were searched for eligible cohort or nes...

AIMS High androgen levels are presumed by many to explain the male predisposition to coronary artery disease. However, natural androgens inhibit male atherosclerosis(1). Our aim was to determine whether levels of androgens differ between men with and without coronary artery disease. METHODS AND RESULTS Ninety male subjects (60 with positive, and 30 with negative coronary angiograms) were recr...

Background: Low testosterone in men with Parkinson’s disease may be associated with non-motor symptoms of the disease, such as apathy. Objective: To determine the association between free serum testosterone level and apathy in elderly men with Parkinson’s disease. Methods: Consecutive non-demented patients (n = 49) and knowledgeable informants (n = 40) participated in the study. Patients and in...

BACKGROUND Low testosterone in men with Parkinson's disease may be associated with non-motor symptoms of the disease, such as apathy. OBJECTIVE To determine the association between free serum testosterone level and apathy in elderly men with Parkinson's disease. METHODS Consecutive non-demented patients (n = 49) and knowledgeable informants (n = 40) participated in the study. Patients and i...

Postmenopausal women with elevated circulating androgen concentrations have an increased risk of developing breast cancer, yet interventions to reduce androgen levels have not been identified. We examined the effects of a 12-month moderate intensity exercise intervention on serum androgens. The study was a randomized clinical trial in 173 sedentary, overweight (body mass index > or = 24.0 kg/m(...

CONTEXT Serum concentrations of gonadal hormones have been associated with various measures of well-being, but it is unclear whether their association with mood is confounded by concurrent physical morbidity. OBJECTIVE To determine whether the association between serum testosterone concentration and mood in older men is independent of physical comorbidity. DESIGN Cross-sectional study. SE...