نتایج جستجو برای: fsgs
تعداد نتایج: 952 فیلتر نتایج به سال:
Trypanolytic variants in APOL1, which encodes apolipoprotein L1, associate with kidney disease in African Americans, but whether APOL1-associated glomerular disease has a distinct clinical phenotype is unknown. Here we determined APOL1 genotypes for 271 African American cases, 168 European American cases, and 939 control subjects. In a recessive model, APOL1 variants conferred seventeenfold hig...
ObjectiveTo increase the likelihood of finding a causative genetic variant in patients with focal segmental glomerulosclerosis (FSGS) lesion, clinical and histologic characteristics were analyzed.Patients MethodsIndividuals 18 years older an FSGS lesion on kidney biopsy evaluated at Mayo Clinic from November 1, 1999, through October 31, 2019, divided into 4 groups based characteristics: primary...
BACKGROUND Focal segmental glomerulosclerosis (FSGS) is the underlying pathologic entity in 5% of adults and 20% of children with end-stage renal disease (ESRD). FSGS is generally considered to be sporadic in origin. METHODS Recently, we identified 60 families involving 190 individuals with familial FSGS, providing evidence for a subset of families in which a genetic form is segregating. Each...
A circulating causative factor has been postulated in focal segmental glomerulosclerosis (FSGS). It has been shown that serum or plasma from some FSGS increases glomerular albumin permeability (Palb) in vitro. Palb greater than 0.5 (i.e., FS activity) is associated with recurrence after transplantation. Specimens from 15 FSGS patients were studied to document the presence of a permeability fact...
BACKGROUND Differential diagnosis between primary focal segmental glomerulosclerosis (FSGS) and minimal change disease (MCD) is sometimes difficult as nephrotic syndrome is the main clinical symptom in both diseases. OBJECTIVES This study has attempted to evaluate the urinary excretion of Th1 and Th2 cytokines as potential biomarkers in distinguishing the two types of nephrotic syndrome, and ...
J.M. Morales, Servicio Nefrología, Hospital 12 Octubre, Ctra. Andalucia km 5.400, E-28041 Madrid (Spain) Dear Sir, Recently, it has been reported that ciclosporin (CsA) may be effective in the treatment of corticoresistant nephrotic syndrome, mainly in minimal change disease [1–3]. The usefulness of CsA in controlling nephrotic syndrome due to focal segmental glomerulosclerosis (FSGS) is contro...
BACKGROUND Soluble urokinase receptor (suPAR) may be involved in the pathological mechanisms of focal segmental glomerulosclerosis (FSGS) changes. However, it remains unclear whether suPAR is correlated with the FSGS-like lesions in IgA nephropathy (IgAN). METHODS We measured the plasma suPAR levels in 138 patients with IgAN, and then their clinical and pathological relationships were analyze...
Patients with primary focal segmental glomerulosclerosis (FSGS) have a high risk of disease recurrence post renal transplantation; this is usually characterised by significant proteinuria and associated with poor graft survival. FSGS recurrence is a challenging medical condition, not only because there is no recognised predictor of FSGS recurrence in the allograft, but also because there are no...
BACKGROUND Focal segmental glomerulosclerosis (FSGS) is a major cause of end-stage renal disease. Recent studies have proposed that plasma soluble urokinase receptor (suPAR) might be a causative circulating factor but this proposal has caused controversy. This study aimed to measure urinary suPAR levels in patients with primary FSGS and its significance in the pathogenesis of FSGS. METHODS Si...
BACKGROUND The classical description of FSGS includes segmental increase of mesangial matrix with obliteration of the capillaries, sclerosis, hyalinosis, foam cells, and segmental scarring, and adhesion between the glomerular tuft and Bowman’s capsule. A recently proposed pathology classification has pointed to the existence of nonsclerotic forms of FSGS. There has been a marked increase in the...
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