Strachan (i968) described a bilateral corneal dystrophy in a 62-year-old man, characterized by punctate, irregular opacities located mainly in the deepest layers of the cornea. The middle and superficial layers were involved to a lesser extent. The size and density of the lesions were sufficient to produce a distorted view of the fundus and to break up the red reflex. Some of the larger opaciti...

Levels of immunoglobulins IgG, IgA, and IgM were measured in 38 patients with myotonic dystrophy, in normal members of their families, and in matched controls. Log IgG was significantly reduced in the patients. IgG investigation provides a further parameter to appraise the status of apparently unaffected members of myotonic dystrophy families.

Aim: Myotonic dystrophy type 1 (DM1) is due to CTG repeats in the 3’UTR region of DMPK gene. It has an incidence of 1 in 8000 in the Western European and North American populations and a lower incidence of 1 in 20,000 in Japan. However, prevalence of the disease in diverse Indian populations is still unknown. Materials and Methods: The intention of the present study was to perform the meta-anal...

PURPOSE Fuchs endothelial corneal dystrophy (FECD) is a genetically heterogeneous disorder that has been primarily studied in patients of European or Asian ancestry. Given the sparse literature on African Americans with FECD, we sought to characterize the genetic variation in three known FECD candidate genes in African American patients with FECD. METHODS Over an 8-year period, we enrolled 47...

PURPOSE To compare the relative expression of peroxiredoxin (Prx) proteins in normal human corneal endothelium with endothelium in corneas affected by Fuchs' endothelial dystrophy (FED) and between normal human endothelium and epithelial/stromal tissue. METHODS Human corneal endothelial cell-Descemet's membrane (HCEC-DM) complexes from normal and FED corneal buttons were dissected from the ep...

PURPOSE MicroRNAs (miRNAs) are a class of endogenous noncoding RNA and post transcriptionally modulate gene expression during development and disease. Our study investigated the differential miRNA expression in human Fuchs' endothelial corneal dystrophy (FECD) compared with normal endothelium to identify miRNA sequences that are involved in the pathogenesis of FECD. METHODS Comparative miRNA ...